| Literature DB >> 16546322 |
Yvan de Launoit1, Jean-Luc Baert, Anne Chotteau-Lelievre, Didier Monte, Laurent Coutte, Sébastien Mauen, Virginie Firlej, Cindy Degerny, Kathye Verreman.
Abstract
The PEA3 group is composed of three highly conserved Ets transcription factors: Erm, Er81, and Pea3. These proteins regulate transcription of multiple genes, and their transactivating potential is affected by post-translational modifications. Among their target genes are several matrix metalloproteases (MMPs), which are enzymes degrading the extracellular matrix during normal remodelling events and cancer metastasis. In fact, PEA3-group genes are often over-expressed in different types of cancers that also over-express these MMPs and display a disseminating phenotype. Experimental regulation of the synthesis of PEA3 group members influences the metastatic process. This suggests that these factors play a key role in metastasis.Entities:
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Year: 2006 PMID： 16546322 DOI： 10.1016/j.bbcan.2006.02.002
Source DB: PubMed Journal: Biochim Biophys Acta ISSN： 0006-3002