| Literature DB >> 16545806 |
Heber Siachoque1, Fanny Guzman, Javier Burgos, Manuel Elkin Patarroyo, Jorge Enrique Gomez Marin.
Abstract
Vaccines are promising for the control of toxoplasmosis. Here, we evaluated the immunogenicity of 17 peptides derived from SAG1 surface protein of Toxoplasma gondii in CH3 mice. Only 8 of 16 peptides induced specific antibodies. After a lethal challenge, only the vaccination with 4 of 17 peptides that were from the carboxy terminal end of the protein conferred significant survival. Our work shows that vaccination with peptides from the carboxy-terminal positions of SAG1 major surface protein of Toxoplasma protects mice against a lethal challenge.Entities:
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Year: 2006 PMID： 16545806 DOI： 10.1016/j.exppara.2006.02.005
Source DB: PubMed Journal: Exp Parasitol ISSN： 0014-4894 Impact factor: 2.011