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Literature DB >> 16544162

Drug discovery from natural products.

Vincent P Gullo¹, James McAlpine, Kin S Lam, Dwight Baker, Frank Petersen.

Abstract

Natural product compounds are the source of numerous therapeutic agents. Recent progress to discover drugs from natural product sources has resulted in compounds that are being developed to treat cancer, resistant bacteria and viruses and immunosuppressive disorders. Many of these compounds were discovered by applying recent advances in understanding the genetics of secondary metabolism in actinomycetes, exploring the marine environment and applying new screening technologies. In many instances, the discovery of a novel natural product serves as a tool to better understand targets and pathways in the disease process. This review describes recent progress in drug discovery from natural sources including several examples of compounds that inhibit novel drug targets.

Entities: Disease

Mesh：

Substances：

Year: 2006 PMID： 16544162 DOI： 10.1007/s10295-006-0107-2

Source DB: PubMed Journal: J Ind Microbiol Biotechnol ISSN： 1367-5435 Impact factor: 3.346

29 in total

1. Salinosporamide A: a highly cytotoxic proteasome inhibitor from a novel microbial source, a marine bacterium of the new genus salinospora.

Authors: Robert H Feling; Greg O Buchanan; Tracy J Mincer; Christopher A Kauffman; Paul R Jensen; William Fenical
Journal: Angew Chem Int Ed Engl Date: 2003-01-20 Impact factor: 15.336

Review 2. Natural products as sources of new drugs over the period 1981-2002.

Authors: David J Newman; Gordon M Cragg; Kenneth M Snader
Journal: J Nat Prod Date: 2003-07 Impact factor: 4.050

Review 3. Affinity capillary electrophoresis analyses of protein-protein interactions in target-directed drug discovery.

Authors: William E Pierceall; Lixin Zhang; Dallas E Hughes
Journal: Methods Mol Biol Date: 2004

Review 4. The need for new antibiotics.

Authors: D M Livermore
Journal: Clin Microbiol Infect Date: 2004-11 Impact factor: 8.067

Review 5. The evolving role of natural products in drug discovery.

Authors: Frank E Koehn; Guy T Carter
Journal: Nat Rev Drug Discov Date: 2005-03 Impact factor: 84.694

Review 6. Antibiotics: where did we go wrong?

Authors: Karen M Overbye; John F Barrett
Journal: Drug Discov Today Date: 2005-01-01 Impact factor: 7.851

Review 7. HSP90 and the chaperoning of cancer.

Authors: Luke Whitesell; Susan L Lindquist
Journal: Nat Rev Cancer Date: 2005-10 Impact factor: 60.716

8. Structure-activity relationship studies of salinosporamide A (NPI-0052), a novel marine derived proteasome inhibitor.

Authors: Venkat R Macherla; Scott S Mitchell; Rama Rao Manam; Katherine A Reed; Ta-Hsiang Chao; Benjamin Nicholson; Gordafaried Deyanat-Yazdi; Bao Mai; Paul R Jensen; William F Fenical; Saskia T C Neuteboom; Kin S Lam; Michael A Palladino; Barbara C M Potts
Journal: J Med Chem Date: 2005-06-02 Impact factor: 7.446

9. Diazepinomicin, a new antimicrobial alkaloid from a marine Micromonospora sp.

Authors: Romila D Charan; Gerhard Schlingmann; Jeffrey Janso; Valerie Bernan; Xidong Feng; Guy T Carter
Journal: J Nat Prod Date: 2004-08 Impact factor: 4.050

10. Capillary electrophoretic approach to screen for enzyme inhibitors in natural extracts.

Authors: Alexei Belenky; Dallas Hughes; Alexei Korneev; Yuriy Dunayevskiy
Journal: J Chromatogr A Date: 2004-10-22 Impact factor: 4.759

21 in total

Review 1. Current status and challenges of cytokine pharmacology.

Authors: Z Zídek; P Anzenbacher; E Kmonícková
Journal: Br J Pharmacol Date: 2009-04-03 Impact factor: 8.739

2. Structural and biochemical analyses of regio- and stereospecificities observed in a type II polyketide ketoreductase.

Authors: Pouya Javidpour; Tyler Paz Korman; Gaurav Shakya; Shiou-Chuan Tsai
Journal: Biochemistry Date: 2011-05-04 Impact factor: 3.162

3. Cloning and expression of the sco2127 gene from Streptomyces coelicolor M145.

Authors: Adán Chávez; Yolanda García-Huante; Beatriz Ruiz; Elizabeth Langley; Romina Rodríguez-Sanoja; Sergio Sanchez
Journal: J Ind Microbiol Biotechnol Date: 2009-02-11 Impact factor: 3.346

4. The sequence of a 1.8-mb bacterial linear plasmid reveals a rich evolutionary reservoir of secondary metabolic pathways.

Authors: Marnix H Medema; Axel Trefzer; Andriy Kovalchuk; Marco van den Berg; Ulrike Müller; Wilbert Heijne; Liang Wu; Mohammad T Alam; Catherine M Ronning; William C Nierman; Roel A L Bovenberg; Rainer Breitling; Eriko Takano
Journal: Genome Biol Evol Date: 2010-07-12 Impact factor: 3.416

Review 5. Antibiotics for emerging pathogens.

Authors: Michael A Fischbach; Christopher T Walsh
Journal: Science Date: 2009-08-28 Impact factor: 47.728