Literature DB >> 16543142

The double-edged sword of Nrf2: subversion of redox homeostasis during the evolution of cancer.

John D Hayes1, Michael McMahon.   

Abstract

Low levels of Nrf2 activity predispose cells to chemical carcinogenesis. Surprisingly, Padmanabhan et al. (2006) provide evidence in a recent issue of Molecular Cell to support the notion that elevated Nrf2 activity may also play a role in the evolution of cancer.

Entities:  

Mesh：

Substances：

Year:  2006        PMID： 16543142     DOI： 10.1016/j.molcel.2006.03.004

Source DB:  PubMed          Journal:  Mol Cell        ISSN： 1097-2765            Impact factor:   17.970


  49 in total

1.  Oxidative stress, mammospheres and Nrf2-new implication for breast cancer therapy?

Authors:  Tongde Wu; Bryan G Harder; Pak K Wong; Julie E Lang; Donna D Zhang
Journal:  Mol Carcinog       Date:  2014-08-23       Impact factor: 4.784

2.  Genetic deletion of Nrf2 promotes immortalization and decreases life span of murine embryonic fibroblasts.

Authors:  Laura Jódar; Evi M Mercken; Julia Ariza; Caitlin Younts; José A González-Reyes; Francisco J Alcaín; Isabel Burón; Rafael de Cabo; José M Villalba
Journal:  J Gerontol A Biol Sci Med Sci       Date:  2010-10-25       Impact factor: 6.053

3.  A combination antioxidant therapy to inhibit NOX2 and activate Nrf2 decreases secondary brain damage and improves functional recovery after traumatic brain injury.

Authors:  Raghavendar Chandran; TaeHee Kim; Suresh L Mehta; Eshwar Udho; Vishal Chanana; Pelin Cengiz; HwuiWon Kim; Chanul Kim; Raghu Vemuganti
Journal:  J Cereb Blood Flow Metab       Date:  2017-10-30       Impact factor: 6.200

4.  Hyperactivity of the transcription factor Nrf2 causes metabolic reprogramming in mouse esophagus.

Authors:  Junsheng Fu; Zhaohui Xiong; Caizhi Huang; Jing Li; Wenjun Yang; Yuning Han; Chorlada Paiboonrungruan; Michael B Major; Ke-Neng Chen; Xiaozheng Kang; Xiaoxin Chen
Journal:  J Biol Chem       Date:  2018-11-08       Impact factor: 5.157

5.  Brusatol overcomes chemoresistance through inhibition of protein translation.

Authors:  Bryan Harder; Wang Tian; James J La Clair; Aik-Choon Tan; Aikseng Ooi; Eli Chapman; Donna D Zhang
Journal:  Mol Carcinog       Date:  2017-02-08       Impact factor: 4.784

6.  p97 Negatively Regulates NRF2 by Extracting Ubiquitylated NRF2 from the KEAP1-CUL3 E3 Complex.

Authors:  Shasha Tao; Pengfei Liu; Gang Luo; Montserrat Rojo de la Vega; Heping Chen; Tongde Wu; Joseph Tillotson; Eli Chapman; Donna D Zhang
Journal:  Mol Cell Biol       Date:  2017-03-31       Impact factor: 4.272

Review 7.  p62/SQSTM1-Dr. Jekyll and Mr. Hyde that prevents oxidative stress but promotes liver cancer.

Authors:  Koji Taniguchi; Shinichiro Yamachika; Feng He; Michael Karin
Journal:  FEBS Lett       Date:  2016-08-06       Impact factor: 4.124

8.  Nrf2 Modulates Host Defense during Streptococcus pneumoniae Pneumonia in Mice.

Authors:  John C Gomez; Hong Dang; Jessica R Martin; Claire M Doerschuk
Journal:  J Immunol       Date:  2016-08-26       Impact factor: 5.422

9.  The WD40 repeat protein WDR-23 functions with the CUL4/DDB1 ubiquitin ligase to regulate nuclear abundance and activity of SKN-1 in Caenorhabditis elegans.

Authors:  Keith P Choe; Aaron J Przybysz; Kevin Strange
Journal:  Mol Cell Biol       Date:  2009-03-09       Impact factor: 4.272

Review 10.  Nrf2 signaling: an adaptive response pathway for protection against environmental toxic insults.

Authors:  William O Osburn; Thomas W Kensler
Journal:  Mutat Res       Date:  2007-11-23       Impact factor: 2.433
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.