Literature DB >> 16542874

Sequence variability and functional analysis of MutS of hypermutable Pseudomonas aeruginosa cystic fibrosis isolates.

Michael Hogardt1, Sören Schubert, Kristin Adler, Monika Götzfried, Jürgen Heesemann.   

Abstract

In this study, we investigated the variability of MutS among Pseudomonas aeruginosa recovered from cystic fibrosis (CF) patients. Sequencing of the mutS gene of 15 hypermutable P. aeruginosa isolates obtained from different patients revealed high rates of nucleotide substitutions as compared to that of strain PAO1. Significantly more synonymous than non-synonymous nucleotide substitutions have been found, indicating that generally MutS is highly conserved. The functional analysis of MutS variants by complementation of a PAO1 mutS mutant revealed 5 isolates with a defective MutS due to frameshift mutations or amino acid substitutions. This work supports the hypothesis that the respiratory tract of CF patients represents an environment that favors the selection of highly adaptive mutator phenotypes.

Entities:  

Mesh：

Substances：

Year:  2006        PMID： 16542874     DOI： 10.1016/j.ijmm.2005.12.018

Source DB:  PubMed          Journal:  Int J Med Microbiol        ISSN： 1438-4221            Impact factor:   3.473


  8 in total

1.  An evolutionary explanation for antibiotics' association with increased colon cancer risk.

Authors:  Konstantinos Voskarides
Journal:  Evol Med Public Health       Date:  2022-04-29

2.  Genetic adaptation of Pseudomonas aeruginosa to the airways of cystic fibrosis patients is catalyzed by hypermutation.

Authors:  A Mena; E E Smith; J L Burns; D P Speert; S M Moskowitz; J L Perez; A Oliver
Journal:  J Bacteriol       Date:  2008-10-10       Impact factor: 3.490

3.  Antibiotic resistance in Pseudomonas aeruginosa strains with increased mutation frequency due to inactivation of the DNA oxidative repair system.

Authors:  L F Mandsberg; O Ciofu; N Kirkby; L E Christiansen; H E Poulsen; N Høiby
Journal:  Antimicrob Agents Chemother       Date:  2009-03-30       Impact factor: 5.191

Review 4.  Airway epithelial control of Pseudomonas aeruginosa infection in cystic fibrosis.

Authors:  Victoria L Campodónico; Mihaela Gadjeva; Catherine Paradis-Bleau; Ahmet Uluer; Gerald B Pier
Journal:  Trends Mol Med       Date:  2008-02-11       Impact factor: 11.951

5.  Mucoidy, quorum sensing, mismatch repair and antibiotic resistance in Pseudomonas aeruginosa from cystic fibrosis chronic airways infections.

Authors:  Sofía Feliziani; Adela M Luján; Alejandro J Moyano; Claudia Sola; José L Bocco; Patricia Montanaro; Liliana Fernández Canigia; Carlos E Argaraña; Andrea M Smania
Journal:  PLoS One       Date:  2010-09-10       Impact factor: 3.240

6.  Clonal dissemination, emergence of mutator lineages and antibiotic resistance evolution in Pseudomonas aeruginosa cystic fibrosis chronic lung infection.

Authors:  Carla López-Causapé; Estrella Rojo-Molinero; Xavier Mulet; Gabriel Cabot; Bartolomé Moyà; Joan Figuerola; Bernat Togores; José L Pérez; Antonio Oliver
Journal:  PLoS One       Date:  2013-08-12       Impact factor: 3.240

7.  Genotypic and phenotypic analyses of a Pseudomonas aeruginosa chronic bronchiectasis isolate reveal differences from cystic fibrosis and laboratory strains.

Authors:  John J Varga; Mariette Barbier; Xavier Mulet; Piotr Bielecki; Jennifer A Bartell; Joshua P Owings; Inmaculada Martinez-Ramos; Lauren E Hittle; Michael R Davis; F Heath Damron; George W Liechti; Jacek Puchałka; Vitor A P Martins dos Santos; Robert K Ernst; Jason A Papin; Sebastian Albertí; Antonio Oliver; Joanna B Goldberg
Journal:  BMC Genomics       Date:  2015-10-30       Impact factor: 3.969

Review 8.  The role of the Pseudomonas aeruginosa hypermutator phenotype on the shift from acute to chronic virulence during respiratory infection.

Authors:  Kalen M Hall; Zachary F Pursell; Lisa A Morici
Journal:  Front Cell Infect Microbiol       Date:  2022-07-22       Impact factor: 6.073
  8 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.