Literature DB >> 1654263

Effects of various mucosal protective drugs on diethyldithiocarbamate-induced antral ulcer in rats.

S Oka1, K Ogino, T Hobara, S Yoshimura, Y Okazaki, T Takemoto, Y Iida.   

Abstract

This study was designed to determine the effects of exogenous Cu,Zn-superoxide dismutase (SOD) and various mucosal protective agents against antral ulcer induced by diethyldithiocarbamate (DDC), inhibitor of Cu,Zn-SOD. Exogenous Cu,Zn-SOD reduced ulcer formation and prevented a decrease in SOD activity in gastric mucosa. This result indicates that maintenance of mucosal SOD activity is essential to prevent the ulcerogenicity of DDC. Many mucosal protective drugs that increase blood flow, mucus secretion, and endogenous prostaglandin failed to prevent ulcer formation and decrease of mucosal SOD activity. Rebamipide, however, significantly reduced ulcerogenesis and maintained mucosal SOD activity. This suggests that rebamipide has new protective effects on gastric mucosa.

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Year:  1991        PMID： 1654263     DOI： 10.1016/0014-2999(91)90370-6

Source DB:  PubMed          Journal:  Eur J Pharmacol        ISSN： 0014-2999            Impact factor:   4.432


  6 in total

1.  Rebamipide reduces delay in gastric ulcer healing in cyclooxygenase-2-deficient mice.

Authors:  Toshio Watanabe; Kazuhide Higuchi; Koichi Taira; Eiji Sasaki; Masatsugu Shiba; Kazunari Tominaga; Yasuhiro Fujiwara; Nobuhide Oshitani; Tetsuo Arakawa
Journal:  Dig Dis Sci       Date:  2005-10       Impact factor: 3.199

2.  Rebamipide prevents delay of acetic acid-induced gastric ulcer healing caused by Helicobacter pylori infection in Mongolian gerbils.

Authors:  Toshio Watanabe; Kazuhide Higuchi; Masaki Hamaguchi; Tetsuya Tanigawa; Rikimon Wada; Kazunari Tominaga; Yasuhiro Fujiwara; Tetsuo Arakawa
Journal:  Dig Dis Sci       Date:  2002-07       Impact factor: 3.199

3.  Rebamipide, a novel antiulcer agent, attenuates Helicobacter pylori induced gastric mucosal cell injury associated with neutrophil derived oxidants.

Authors:  M Suzuki; S Miura; M Mori; A Kai; H Suzuki; D Fukumura; M Suematsu; M Tsuchiya
Journal:  Gut       Date:  1994-10       Impact factor: 23.059

4.  Active oxygen species in formation of acute gastric mucosal lesions induced by thermal injury in rats.

Authors:  M Yoshida; T Kitahora; G Wakabayashi; H Tashiro; H Ono; Y Otani; M Shimazu; T Kubota; K Kumai; M Kitajima
Journal:  Dig Dis Sci       Date:  1995-06       Impact factor: 3.199

5.  Preventive effects of rebamipide on NSAID-induced gastric mucosal injury and reduction of gastric mucosal blood flow in healthy volunteers.

Authors:  Hyung-Keun Kim; Jin-Il Kim; Jae-Kwang Kim; Joon-Yeol Han; Soo-Heon Park; Kyu-Yong Choi; In-Sik Chung
Journal:  Dig Dis Sci       Date:  2007-04-05       Impact factor: 3.487

6.  Preliminary trial of rebamipide for prevention of low-dose aspirin-induced gastric injury in healthy subjects: a randomized, double-blind, placebo-controlled, cross-over study.

Authors:  Shouko Ono; Mototsugu Kato; Aki Imai; Takeshi Yoshida; Jyojyo Hirota; Tamotsu Hata; Kikuko Takagi; Go Kamada; Yuji Ono; Manabu Nakagawa; Souichi Nakagawa; Yuichi Shimizu; Hiroshi Takeda; Masahiro Asaka
Journal:  J Clin Biochem Nutr       Date:  2009-08-28       Impact factor: 3.114
  6 in total

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