| Literature DB >> 16542345 |
L-D Liu1, C-H Dong, H-J Shi, H-L Zhao, L-C Wang, S-H Ma, Q-H Li.
Abstract
A type II membrane protein similar to CD69 (TIIMPSC) has been isolated in human embryo fibroblasts treated with IFN-alpha. Structural analysis and immunofluorescence detection has suggested that this protein is located on the surface of fibroblasts, generally considered, a receptor. Cell proliferation assay has revealed that activation of TIIMPSC elevates the level of fibroblast proliferation. Further, examination of signal transduction has indicated that expression of this protein is up-regulated by IFN-alpha stimulation, and that it is involved in the regulation of fibroblast growth through the JAK-STAT signalling pathway.Entities:
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Year: 2006 PMID： 16542345 PMCID： PMC6496284 DOI： 10.1111/j.1365-2184.2006.00373.x
Source DB: PubMed Journal: Cell Prolif ISSN： 0960-7722 Impact factor: 6.831