Literature DB >> 16542154

Human plasma adenosine deaminase 2 is secreted by activated monocytes.

Sachiko Iwaki-Egawa1, Takaya Yamamoto, Yasuhiro Watanabe.   

Abstract

Adenosine deaminase (ADA) plays an important role in the immune system, and its activity is composed of two kinetically distinct isozymes, ADA1 and ADA2. ADA2 is a major component of human plasma total ADA activity and ADA2 activity is significantly elevated in patients with various diseases such as HIV infection and chronic hepatitis. However, relatively little is known about ADA2 because of difficulties in purifying this enzyme. In this study we succeeded in purifying human plasma ADA2 and demonstrate the extracellular secretion of ADA2 from human peripheral blood monocytes stimulated with phorbol 12-myristate 13-acetate and calcium ionophore.

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Year:  2006        PMID： 16542154     DOI： 10.1515/BC.2006.042

Source DB:  PubMed          Journal:  Biol Chem        ISSN： 1431-6730            Impact factor:   3.915


  19 in total

1.  Adenosine deaminase activity in serum and lymphocytes of rats infected with Sporothrix schenckii.

Authors:  Verônica S P Castro; Victor C Pimentel; Aleksandro S Da Silva; Gustavo R Thomé; Patrícia Wolkmer; Jorge L C Castro; Márcio M Costa; Cássia B da Silva; Daniele C Oliveira; Sydney H Alves; Maria R C Schetinger; Sonia T A Lopes; Cinthia M Mazzanti
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Review 2.  Molecular mechanisms of phenotypic variability in monogenic autoinflammatory diseases.

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3.  A novel association of adenosine deaminase with paroxysmal atrial fibrillation: a propensity score analysis from a case-control study.

Authors:  Liang Liu; Yong-Ming He; Cui-Fen Hu; Xin Zhao; Hai-Feng Xu; Xiang-Jun Yang
Journal:  J Thorac Dis       Date:  2015-04       Impact factor: 2.895

Review 4.  NETosis in Rheumatic Diseases.

Authors:  Mehul P Jariwala; Ronald M Laxer
Journal:  Curr Rheumatol Rep       Date:  2021-01-28       Impact factor: 4.592

Review 5.  The Immunogenetics of Vasculitis.

Authors:  Fotini B Karassa; Eleftherios Pelechas; Georgios Zouzos
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Review 6.  New players driving inflammation in monogenic autoinflammatory diseases.

Authors:  Fabio Martinon; Ivona Aksentijevich
Journal:  Nat Rev Rheumatol       Date:  2014-09-23       Impact factor: 20.543

7.  Comparison of adenosine deaminase levels in serum and synovial fluid between patients with rheumatoid arthritis and osteoarthritis.

Authors:  Zahra Zakeri; Shahrokh Izadi; Abassali Niazi; Zohre Bari; Soodabeh Zendeboodi; Mansoor Shakiba; Mohammadali Mashhadi; Behzad Narouie; Mohammad Ghasemi-Rad
Journal:  Int J Clin Exp Med       Date:  2012-04-06

Review 8.  Deficiency of Adenosine Deaminase 2 (DADA2), an Inherited Cause of Polyarteritis Nodosa and a Mimic of Other Systemic Rheumatologic Disorders.

Authors:  Hasan Hashem; Susan J Kelly; Nancy J Ganson; Michael S Hershfield
Journal:  Curr Rheumatol Rep       Date:  2017-10-05       Impact factor: 4.592

9.  Adenosine deaminase 2 as a biomarker of macrophage activation syndrome in systemic juvenile idiopathic arthritis.

Authors:  Pui Y Lee; Grant S Schulert; Scott W Canna; Yuelong Huang; Jacob Sundel; Ying Li; Kacie J Hoyt; Rachel B Blaustein; Alexandra Wactor; Thuy Do; Olha Halyabar; Margaret H Chang; Fatma Dedeoglu; Siobhan M Case; Esra Meidan; Mindy S Lo; Robert P Sundel; Edward T Richardson; Jane W Newburger; Michael S Hershfield; Mary Beth Son; Lauren A Henderson; Peter A Nigrovic
Journal:  Ann Rheum Dis       Date:  2019-11-09       Impact factor: 19.103

10.  DNMT3A haploinsufficiency causes dichotomous DNA methylation defects at enhancers in mature human immune cells.

Authors:  Jung-Yeon Lim; Sascha H Duttke; Turner S Baker; Jihye Lee; Kristyne J Gambino; Nicholas J Venturini; Jessica Sook Yuin Ho; Simin Zheng; Yesai S Fstkchyan; Vinodh Pillai; David C Fajgenbaum; Ivan Marazzi; Christopher Benner; Minji Byun
Journal:  J Exp Med       Date:  2021-05-10       Impact factor: 17.579
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