| Literature DB >> 16541315 |
J Lubiński1, B Górski, T Huzarski, T Byrski, J Gronwald, P Serrano-Fernández, W Domagała, M Chosia, M Uciński, E Grzybowska, D Lange, B Maka, A Mackiewicz, A Karczewska, J Breborowicz, K Lamperska, M Stawicka, S Gozdecka-Grodecka, M Bebenek, D Sorokin, A Wojnar, O Haus, J Sir, T Mierzwa, S Niepsuj, K Gugała, S Góźdź, J Sygut, B Kozak-Klonowska, B Musiatowicz, M Posmyk, R Kordek, M Morawiec, O Zambrano, B Waśko, L Fudali, J Skret, D Surdyka, K Urbański, J Mituś, J Ryś, M Szwiec, A Rozmiarek, I Dziuba, P Wandzel, R Wiśniowski, C Szczylik, A Kozak, W Kozłowski, S A Narod.
Abstract
We identified 4316 unselected incident cases of early-onset breast cancers (<51 ears of age at diagnosis) in 18 Polish hospitals between 1996 and 2003. We were able to obtain a blood sample for DNA analysis from 3472 of these (80.4%). All cases were tested for the presence of three founder mutations in BRCA1. The proportion of cases with a BRCA1 mutation was 5.7%. The hereditary proportions were higher than this for women with breast cancer diagnosed before age 40 (9%), for women with cancer of medullary or atypical medullary histology (28%), for those with bilateral cancer (29%) or with a family history of breast or ovarian cancer (13%). It is reasonable to offer genetic testing to women with early-onset breast cancer in Poland.Entities:
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Year: 2006 PMID： 16541315 DOI： 10.1007/s10549-006-9182-3
Source DB: PubMed Journal: Breast Cancer Res Treat ISSN： 0167-6806 Impact factor: 4.872