Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Viral involvement in Hodgkin's disease: detection of clonal type A Epstein-Barr virus genomes in tumour samples.

Literature DB >> 1654072

Viral involvement in Hodgkin's disease: detection of clonal type A Epstein-Barr virus genomes in tumour samples.

S Gledhill¹, A Gallagher, D B Jones, A S Krajewski, F E Alexander, E Klee, D H Wright, C O'Brien, D E Onions, R F Jarrett.

Abstract

Thirty-five cases of Hodgkin's disease (HD) were analysed for the presence of Epstein-Barr virus (EBV) and human herpesvirus-6 (HHV-6) DNA. EBV genomes were detected in 11/35 cases while none of the cases was positive for HHV-6. Ten of the EBV-positive cases were subsequently analysed using a probe for the terminal region of the virus; the results suggested that the EBV-infected cells were clonally expanded. EBV subtypes specific DNA amplification was used to demonstrate that EBV subtype A, and not subtype B was present in the EBV-positive cases. The age distribution of the EBV-positive cases indicated a statistically significant trend for an increase in positivity with increasing age. This is the first indication that EBV is significantly associated with any subset of HD patients.

Entities: Disease Species

Mesh：

Substances：
DNA, Viral

Year: 1991 PMID： 1654072 PMCID： PMC1977506 DOI： 10.1038/bjc.1991.281

Source DB: PubMed Journal: Br J Cancer ISSN： 0007-0920 Impact factor: 7.640

38 in total

1. Demonstration of Epstein-Barr viral DNA in formalin-fixed, paraffin-embedded samples of Hodgkin's disease.

Authors: C M Libetta; J H Pringle; C A Angel; A W Craft; A J Malcolm; I Lauder
Journal: J Pathol Date: 1990-07 Impact factor: 7.996

2. Detection of a second widespread strain of Epstein-Barr virus.

Authors: J W Sixbey; P Shirley; P J Chesney; D M Buntin; L Resnick
Journal: Lancet Date: 1989-09-30 Impact factor: 79.321

Review 3. Genotypic analysis of lymph node biopsies.

Authors: N T O'Connor
Journal: J Pathol Date: 1987-03 Impact factor: 7.996

4. Influence of the Epstein-Barr virus nuclear antigen EBNA 2 on the growth phenotype of virus-transformed B cells.

Authors: A B Rickinson; L S Young; M Rowe
Journal: J Virol Date: 1987-05 Impact factor: 5.103

5. Epstein-Barr virus-transformed human precursor B cell lines: altered growth phenotype of lines with germ-line or rearranged but nonexpressed heavy chain genes.

Authors: C D Gregory; C Kirchgens; C F Edwards; L S Young; M Rowe; A Forster; T H Rabbitts; A B Rickinson
Journal: Eur J Immunol Date: 1987-08 Impact factor: 5.532

6. Genomic analysis of the human B-lymphotropic virus (HBLV).

Authors: S F Josephs; S Z Salahuddin; D V Ablashi; F Schachter; F Wong-Staal; R C Gallo
Journal: Science Date: 1986-10-31 Impact factor: 47.728

7. Analysis of T-cell receptor and immunoglobulin gene rearrangements in the diagnosis of Hodgkin's and non-Hodgkin's lymphoma.

Authors: S Gledhill; A S Krajewski; A E Dewar; D E Onions; R F Jarrett
Journal: J Pathol Date: 1990-07 Impact factor: 7.996

8. The c-myc gene paradox in Burkitt's lymphoma chromosomal translocation.

Authors: T H Rabbitts; R Baer; M Davis; A Forster; P H Hamlyn; S Malcolm
Journal: Curr Top Microbiol Immunol Date: 1984 Impact factor: 4.291

9. Epstein-Barr virus types 1 and 2 differ in their EBNA-3A, EBNA-3B, and EBNA-3C genes.

Authors: J Sample; L Young; B Martin; T Chatman; E Kieff; A Rickinson; E Kieff
Journal: J Virol Date: 1990-09 Impact factor: 5.103

10. A uniform deleting element mediates the loss of kappa genes in human B cells.

Authors: K A Siminovitch; A Bakhshi; P Goldman; S J Korsmeyer
Journal: Nature Date: 1985 Jul 18-24 Impact factor: 49.962

11 in total

1. Epidemiology of infection with Epstein-Barr virus types 1 and 2: lessons from the study of a T-cell-immunocompromised hemophilic cohort.

Authors: Q Y Yao; D S Croom-Carter; R J Tierney; G Habeshaw; J T Wilde; F G Hill; C Conlon; A B Rickinson
Journal: J Virol Date: 1998-05 Impact factor: 5.103

2. Conservation of Epstein-Barr virus cytotoxic T-cell epitopes in posttransplant lymphomas: implications for immune therapy.

Authors: Qian Tao; Jie Yang; He Huang; Lode J Swinnen; Richard F Ambinder
Journal: Am J Pathol Date: 2002-05 Impact factor: 4.307

Viral involvement in Hodgkin's disease: detection of clonal type A Epstein-Barr virus genomes in tumour samples.

1. Demonstration of Epstein-Barr viral DNA in formalin-fixed, paraffin-embedded samples of Hodgkin's disease.

2. Detection of a second widespread strain of Epstein-Barr virus.

Review 3. Genotypic analysis of lymph node biopsies.

4. Influence of the Epstein-Barr virus nuclear antigen EBNA 2 on the growth phenotype of virus-transformed B cells.

5. Epstein-Barr virus-transformed human precursor B cell lines: altered growth phenotype of lines with germ-line or rearranged but nonexpressed heavy chain genes.

6. Genomic analysis of the human B-lymphotropic virus (HBLV).

7. Analysis of T-cell receptor and immunoglobulin gene rearrangements in the diagnosis of Hodgkin's and non-Hodgkin's lymphoma.

8. The c-myc gene paradox in Burkitt's lymphoma chromosomal translocation.

9. Epstein-Barr virus types 1 and 2 differ in their EBNA-3A, EBNA-3B, and EBNA-3C genes.

10. A uniform deleting element mediates the loss of kappa genes in human B cells.

1. Epidemiology of infection with Epstein-Barr virus types 1 and 2: lessons from the study of a T-cell-immunocompromised hemophilic cohort.

2. Conservation of Epstein-Barr virus cytotoxic T-cell epitopes in posttransplant lymphomas: implications for immune therapy.

Review 3. Detection and characterization of Epstein-Barr virus in clinical specimens.

4. The impact of EBV, proliferation rate, and Bcl-2 expression in Hodgkin's disease in childhood.

5. Association of Epstein-Barr virus with pediatric Hodgkin's disease.

6. 11. Cancers attributable to infection in the UK in 2010.

7. Lack of involvement of known oncogenic DNA viruses in Epstein-Barr virus-negative Hodgkin's disease.

8. Association of HHV-6 with Hodgkin and non Hodgkin lymphoma.

Review 9. Human Herpesvirus 6 and Malignancy: A Review.

Review 10. Estimating the global burden of Epstein-Barr virus-related cancers.