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Literature DB >> 16539862

Is serotonin hyperalgesic or analgesic?

Abstract

Serotonin (5-hydroxtryptamine, 5-HT) is an important molecule in pain processing and modulation. Whether 5-HT has an analgesic or hyperalgesic action depends on the cell type and type of receptor it acts on. In the periphery, 5-HT sensitizes afferent nerve fibers, thus contributing to hyperalgesia in inflammation and nerve injury. In the trigeminal system, agonism at 5-HT1B/D receptors reduces neurotransmitter release, but actions through the 5-HT2A receptor may underlie chronic headache. Furthermore, genetic alterations in the 5-HT system may influence the susceptibility to migraine. In the central nervous system, 5-HT is involved in descending inhibition, but facilitatory serotonergic pathways may be functionally more important.

Entities: Chemical

Mesh：

Substances：

Year: 2006 PMID： 16539862 DOI： 10.1007/s11916-006-0020-4

Source DB: PubMed Journal: Curr Pain Headache Rep ISSN： 1534-3081

72 in total

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20 in total

1. Association Between Sumatriptan Treatment During a Migraine Attack and Central 5-HT1B Receptor Binding.

Authors: Marie Deen; Anders Hougaard; Hanne Demant Hansen; Martin Schain; Agnete Dyssegaard; Gitte Moos Knudsen; Messoud Ashina
Journal: JAMA Neurol Date: 2019-07-01 Impact factor: 18.302

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Authors: Daniel Jonsson; Oscar Finskas; Yuki Fujioka; Anders Ståhlberg; Kjell Olmarker
Journal: Clin Orthop Relat Res Date: 2015-06 Impact factor: 4.176

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Authors: Maria Esposito; Maria Ruberto; Antonio Pascotto; Marco Carotenuto
Journal: Neurol Sci Date: 2012-03-23 Impact factor: 3.307

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Authors: M Barann; U M Stamer; M Lyutenska; F Stüber; H Bönisch; B Urban
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Journal: Mol Pain Date: 2009-07-01 Impact factor: 3.395

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Authors: Fredrik Lindstedt; Bianka Karshikoff; Martin Schalling; Caroline Olgart Höglund; Martin Ingvar; Mats Lekander; Eva Kosek
Journal: PLoS One Date: 2012-08-31 Impact factor: 3.240