| Literature DB >> 16538859 |
S Prabhu1, Mallika Jainu, K E Sabitha, C S Shyamala Devi.
Abstract
Isoproterenol (ISPH) induced myocardial infarction was confirmed by disturbances in serum and heart tissue marker enzymes such as lactate dehydrogenase (LDH), creatine phospho kinase (CPK), aspartate transaminase (AST) and alanine transaminase (ALT), increased level of lipid peroxidation and histopathological changes in the heart of ISPH administered rats. Pretreatment with mangiferin (10 mg/100 g body weight) for 28 days was found to ameliorate the effect of ISPH-induced pathological changes, reduced the lipid peroxide formation and retained the myocardial marker enzyme activities at near normal level. The above results indicate the cardioprotective effect of mangiferin against ISPH-induced myocardial infarction in rats.Entities:
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Year: 2006 PMID: 16538859
Source DB: PubMed Journal: Indian J Exp Biol ISSN: 0019-5189 Impact factor: 0.818