OBJECTIVE: There is growing evidence of a link between type 2 diabetes and breast cancer, possibly through insulin resistance and/or hyperinsulinemia. Because insulin levels are at their highest prior to the development of diabetes, breast cancer risk may be even greater during the pre-diabetes period. RESEARCH DESIGN AND METHODS: In this cross-sectional study, women aged 55-79 years living in Ontario, Canada, with newly diagnosed diabetes from 1994 to 2002 were identified from a validated, population-based database (N = 82,390). Prior history of breast cancer in this group was recorded from 1964 until their diabetes diagnosis from a linkable cancer registry, and was compared to a similarly aged comparison group without diabetes (N = 411,950). RESULTS: Prior breast cancers were identified in 3.7% of women with diabetes and in 3.1% women without diabetes (odds ratio, OR 1.22, 95% confidence interval, CI 1.17-1.27, p < 0.0001). The mean time from breast cancer diagnosis to diabetes diagnosis was 7.9 years. The likelihood of a breast cancer history remained significantly higher in women with diabetes after adjustment for age, income and physician visits (OR 1.13, 95% CI 1.09-1.18, p < 0.0001). CONCLUSIONS: These results suggest that breast cancer risk may be increased in the pre-diabetes phase and may have implications for screening and prevention strategies. Further studies are required to better characterize the processes that link insulin resistance, diabetes and breast cancer.
OBJECTIVE: There is growing evidence of a link between type 2 diabetes and breast cancer, possibly through insulin resistance and/or hyperinsulinemia. Because insulin levels are at their highest prior to the development of diabetes, breast cancer risk may be even greater during the pre-diabetes period. RESEARCH DESIGN AND METHODS: In this cross-sectional study, women aged 55-79 years living in Ontario, Canada, with newly diagnosed diabetes from 1994 to 2002 were identified from a validated, population-based database (N = 82,390). Prior history of breast cancer in this group was recorded from 1964 until their diabetes diagnosis from a linkable cancer registry, and was compared to a similarly aged comparison group without diabetes (N = 411,950). RESULTS: Prior breast cancers were identified in 3.7% of women with diabetes and in 3.1% women without diabetes (odds ratio, OR 1.22, 95% confidence interval, CI 1.17-1.27, p < 0.0001). The mean time from breast cancer diagnosis to diabetes diagnosis was 7.9 years. The likelihood of a breast cancer history remained significantly higher in women with diabetes after adjustment for age, income and physician visits (OR 1.13, 95% CI 1.09-1.18, p < 0.0001). CONCLUSIONS: These results suggest that breast cancer risk may be increased in the pre-diabetes phase and may have implications for screening and prevention strategies. Further studies are required to better characterize the processes that link insulin resistance, diabetes and breast cancer.
Authors: Soley Bayraktar; Leonel F Hernadez-Aya; Xiudong Lei; Funda Meric-Bernstam; Jennifer K Litton; Limin Hsu; Gabriel N Hortobagyi; Ana M Gonzalez-Angulo Journal: Cancer Date: 2011-07-28 Impact factor: 6.860
Authors: Michael Bodmer; Christian Meier; Stephan Krähenbühl; Susan S Jick; Christoph R Meier Journal: Diabetes Care Date: 2010-03-18 Impact factor: 19.112
Authors: Ruth E Patterson; Shirley W Flatt; Nazmus Saquib; Cheryl L Rock; Bette J Caan; Barbara A Parker; Gail A Laughlin; Kirsten Erickson; Cynthia A Thomson; Wayne A Bardwell; Richard A Hajek; John P Pierce Journal: Breast Cancer Res Treat Date: 2010-01-14 Impact factor: 4.872
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