AIMS/HYPOTHESIS: The association between IL4R and type 1 diabetes has been tested in many studies in recent years, with contradictory results. The aim of this study was to re-evaluate the genetic association in type 1 diabetic nuclear families of mixed European background. SUBJECTS, MATERIALS AND METHODS: We genotyped six non-synonymous single-nucleotide polymorphisms (SNPs) of the IL4R gene in 830 nuclear families as specified above, including a French Canadian subset. RESULTS: No association between type 1 diabetes and any SNP or haplotype was found by the transmission disequilibrium test. CONCLUSIONS/ INTERPRETATION: Previous positive reports may be due to population stratification as, according to HapMap data, allele frequencies in the IL4R region vary considerably by ethnicity.
AIMS/HYPOTHESIS: The association between IL4R and type 1 diabetes has been tested in many studies in recent years, with contradictory results. The aim of this study was to re-evaluate the genetic association in type 1 diabetic nuclear families of mixed European background. SUBJECTS, MATERIALS AND METHODS: We genotyped six non-synonymous single-nucleotide polymorphisms (SNPs) of the IL4R gene in 830 nuclear families as specified above, including a French Canadian subset. RESULTS: No association between type 1 diabetes and any SNP or haplotype was found by the transmission disequilibrium test. CONCLUSIONS/ INTERPRETATION: Previous positive reports may be due to population stratification as, according to HapMap data, allele frequencies in the IL4R region vary considerably by ethnicity.
Authors: Daniel B Mirel; Ana Maria Valdes; Laura C Lazzeroni; Rebecca L Reynolds; Henry A Erlich; Janelle A Noble Journal: Diabetes Date: 2002-11 Impact factor: 9.461
Authors: L M Maier; R C J Twells; J M M Howson; A C Lam; D G Clayton; D J Smyth; D Savage; D Carson; C C Patterson; L J Smink; N M Walker; O S Burren; S Nutland; H Rance; E Tuomilehto-Wolf; J Tuomilehto; C Guja; C Ionescu-Tirgoviste; D E Undlien; K S Rønningen; F Cucca; J A Todd Journal: Genes Immun Date: 2003-10 Impact factor: 2.676
Authors: Teodorica L Bugawan; Daniel B Mirel; Ana M Valdes; Araceli Panelo; Paolo Pozzilli; Henry A Erlich Journal: Am J Hum Genet Date: 2003-05-13 Impact factor: 11.025