BACKGROUND: The thermic effect of food (TEF) is higher in lean than in obese human subjects. OBJECTIVE: Relationships between TEF and insulin resistance during meals, from the point of view of autonomic nervous activity, were evaluated. METHODS: Autonomic nervous activity was evaluated in 20 young adults using the spectral analysis of heart rate variability from one hour before to two hours after a meal. Heart rate data were analyzed based on low frequency components (LF power, 0.04-0.15 Hz), high frequency components (HF power, 0.15-0.40 Hz), and LF/HF ratios. Energy expenditure and the TEF were measured 30 min after a meal. Homeostasis model of insulin resistance index (HOMA-IR) was also measured. RESULTS: The LF/HF ratio was significantly increased 30 min after a meal (p<0.05). No correlation between LF power and HF power with TEF was found, but the LF/HF ratio was significantly and positively correlated with TEF (r=+0.56, p<0.05). Moreover, a significant negative correlation was found between the HOMA-IR and TEF (r=-0.601, p<0.05). CONCLUSIONS: The findings suggest that a reduction in insulin sensitivity induces a poor response of sympathetic nervous activity in the postprandial phase and a reduction in postprandial energy expenditure.
BACKGROUND: The thermic effect of food (TEF) is higher in lean than in obesehuman subjects. OBJECTIVE: Relationships between TEF and insulin resistance during meals, from the point of view of autonomic nervous activity, were evaluated. METHODS: Autonomic nervous activity was evaluated in 20 young adults using the spectral analysis of heart rate variability from one hour before to two hours after a meal. Heart rate data were analyzed based on low frequency components (LF power, 0.04-0.15 Hz), high frequency components (HF power, 0.15-0.40 Hz), and LF/HF ratios. Energy expenditure and the TEF were measured 30 min after a meal. Homeostasis model of insulin resistance index (HOMA-IR) was also measured. RESULTS: The LF/HF ratio was significantly increased 30 min after a meal (p<0.05). No correlation between LF power and HF power with TEF was found, but the LF/HF ratio was significantly and positively correlated with TEF (r=+0.56, p<0.05). Moreover, a significant negative correlation was found between the HOMA-IR and TEF (r=-0.601, p<0.05). CONCLUSIONS: The findings suggest that a reduction in insulin sensitivity induces a poor response of sympathetic nervous activity in the postprandial phase and a reduction in postprandial energy expenditure.
Authors: Elizabeth F Sutton; George A Bray; Jeffrey H Burton; Steven R Smith; Leanne M Redman Journal: Obesity (Silver Spring) Date: 2016-06-29 Impact factor: 5.002
Authors: Agnieszka Kozacz; Paulina Grunt; Marta Steczkowska; Tomasz Mikulski; Jan Dąbrowski; Monika Górecka; Urszula Sanocka; Andrzej Wojciech Ziemba Journal: Int J Endocrinol Date: 2014-03-10 Impact factor: 3.257