Literature DB >> 16537635

Brd4 is involved in multiple processes of the bovine papillomavirus type 1 life cycle.

Ivar Ilves1, Kristina Mäemets, Toomas Silla, Kadri Janikson, Mart Ustav.   

Abstract

Brd4 protein has been proposed to act as a cellular receptor for the bovine papillomavirus type 1 (BPV1) E2 protein in the E2-mediated chromosome attachment and mitotic segregation of viral genomes. Here, we provide data that show the involvement of Brd4 in multiple early functions of the BPV1 life cycle, suggest a Brd4-dependent mechanism for E2-dependent transcription activation, and indicate the role of Brd4 in papillomavirus and polyomavirus replication as well as cell-specific utilization of Brd4-linked features in BPV1 DNA replication. Our data also show the potential therapeutic value of the disruption of the E2-Brd4 interaction for the development of antiviral drugs.

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Year:  2006        PMID： 16537635      PMCID： PMC1440376          DOI： 10.1128/JVI.80.7.3660-3665.2006

Source DB:  PubMed          Journal:  J Virol        ISSN： 0022-538X            Impact factor:   5.103


  25 in total

1.  Monitoring and purification of proteins using bovine papillomavirus E2 epitope tags.

Authors:  N Kaldalu; D Lepik; A Kristjuhan; M Ustav
Journal:  Biotechniques       Date:  2000-03       Impact factor: 1.993

2.  Inhibition of E2 binding to Brd4 enhances viral genome loss and phenotypic reversion of bovine papillomavirus-transformed cells.

Authors:  Jianxin You; Michal-Ruth Schweiger; Peter M Howley
Journal:  J Virol       Date:  2005-12       Impact factor: 5.103

3.  Interaction of bovine papillomavirus E2 protein with Brd4 stabilizes its association with chromatin.

Authors:  Maria G McPhillips; Keiko Ozato; Alison A McBride
Journal:  J Virol       Date:  2005-07       Impact factor: 5.103

4.  The bromodomain protein Brd4 is a positive regulatory component of P-TEFb and stimulates RNA polymerase II-dependent transcription.

Authors:  Moon Kyoo Jang; Kazuki Mochizuki; Meisheng Zhou; Ho-Sang Jeong; John N Brady; Keiko Ozato
Journal:  Mol Cell       Date:  2005-08-19       Impact factor: 17.970

5.  Recruitment of P-TEFb for stimulation of transcriptional elongation by the bromodomain protein Brd4.

Authors:  Zhiyuan Yang; Jasper H N Yik; Ruichuan Chen; Nanhai He; Moon Kyoo Jang; Keiko Ozato; Qiang Zhou
Journal:  Mol Cell       Date:  2005-08-19       Impact factor: 17.970

6.  Association of bovine papillomavirus E2 protein with nuclear structures in vivo.

Authors:  Reet Kurg; Kristiina Sild; Aigi Ilves; Mari Sepp; Mart Ustav
Journal:  J Virol       Date:  2005-08       Impact factor: 5.103

7.  Reconstitution of papillomavirus E2-mediated plasmid maintenance in Saccharomyces cerevisiae by the Brd4 bromodomain protein.

Authors:  Angela R Brannon; Julia A Maresca; Jef D Boeke; Munira A Basrai; Alison A McBride
Journal:  Proc Natl Acad Sci U S A       Date:  2005-02-14       Impact factor: 11.205

8.  Episomal maintenance of plasmids with hybrid origins in mouse cells.

Authors:  Toomas Silla; Ingrid Hääl; Jelizaveta Geimanen; Kadri Janikson; Aare Abroi; Ene Ustav; Mart Ustav
Journal:  J Virol       Date:  2005-12       Impact factor: 5.103

9.  Polyomavirus small t antigen: overproduction in bacteria, purification, and utilization for monoclonal and polyclonal antibody production.

Authors:  D C Pallas; C Schley; M Mahoney; E Harlow; B S Schaffhausen; T M Roberts
Journal:  J Virol       Date:  1986-12       Impact factor: 5.103

10.  The mitotic chromosome binding activity of the papillomavirus E2 protein correlates with interaction with the cellular chromosomal protein, Brd4.

Authors:  Michael K Baxter; Maria G McPhillips; Keiko Ozato; Alison A McBride
Journal:  J Virol       Date:  2005-04       Impact factor: 5.103
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  49 in total

1.  Interaction of the papillomavirus E8--E2C protein with the cellular CHD6 protein contributes to transcriptional repression.

Authors:  Jasmin Fertey; Ingo Ammermann; Michael Winkler; Reinhard Stöger; Thomas Iftner; Frank Stubenrauch
Journal:  J Virol       Date:  2010-07-14       Impact factor: 5.103

Review 2.  Hitchhiking on host chromatin: how papillomaviruses persist.

Authors:  Alison A McBride; Nozomi Sakakibara; Wesley H Stepp; Moon Kyoo Jang
Journal:  Biochim Biophys Acta       Date:  2012-01-28

Review 3.  BET domain co-regulators in obesity, inflammation and cancer.

Authors:  Anna C Belkina; Gerald V Denis
Journal:  Nat Rev Cancer       Date:  2012-06-22       Impact factor: 60.716

4.  Characterization of the functional activities of the bovine papillomavirus type 1 E2 protein single-chain heterodimers.

Authors:  Reet Kurg; Helena Tekkel; Aare Abroi; Mart Ustav
Journal:  J Virol       Date:  2006-08-30       Impact factor: 5.103

5.  Brd4 is required for e2-mediated transcriptional activation but not genome partitioning of all papillomaviruses.

Authors:  M G McPhillips; J G Oliveira; J E Spindler; R Mitra; A A McBride
Journal:  J Virol       Date:  2006-10       Impact factor: 5.103

6.  Brd4-independent transcriptional repression function of the papillomavirus e2 proteins.

Authors:  Michal-Ruth Schweiger; Matthias Ottinger; Jianxin You; Peter M Howley
Journal:  J Virol       Date:  2007-07-11       Impact factor: 5.103

Review 7.  Replication and partitioning of papillomavirus genomes.

Authors:  Alison A McBride
Journal:  Adv Virus Res       Date:  2008       Impact factor: 9.937

8.  The interaction of the gammaherpesvirus 68 orf73 protein with cellular BET proteins affects the activation of cell cycle promoters.

Authors:  Matthias Ottinger; Daniel Pliquet; Thomas Christalla; Ronald Frank; James P Stewart; Thomas F Schulz
Journal:  J Virol       Date:  2009-02-25       Impact factor: 5.103

9.  BET bromodomain inhibitors show anti-papillomavirus activity in vitro and block CRPV wart growth in vivo.

Authors:  Mary A Morse; Karla K Balogh; Sarah A Brendle; Colin A Campbell; Mao X Chen; Rebecca C Furze; Isobel L Harada; Ian D Holyer; Umesh Kumar; Kevin Lee; Rab K Prinjha; Martin Rüdiger; Jonathan T Seal; Simon Taylor; Jason Witherington; Neil D Christensen
Journal:  Antiviral Res       Date:  2018-04-11       Impact factor: 5.970

10.  Cell-type specific transcriptional activities among different papillomavirus long control regions and their regulation by E2.

Authors:  Matthias Ottinger; Jennifer A Smith; Michal-Ruth Schweiger; Dana Robbins; Maria L C Powell; Jianxin You; Peter M Howley
Journal:  Virology       Date:  2009-12-20       Impact factor: 3.616
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