| Literature DB >> 16537443 |
Ahmed Regina1, Anthony Bird, David Topping, Sarah Bowden, Judy Freeman, Tina Barsby, Behjat Kosar-Hashemi, Zhongyi Li, Sadequr Rahman, Matthew Morell.
Abstract
Foods high in resistant starch have the potential to improve human health and lower the risk of serious noninfectious diseases. RNA interference was used to down-regulate the two different isoforms of starch-branching enzyme (SBE) II (SBEIIa and SBEIIb) in wheat endosperm to raise its amylose content. Suppression of SBEIIb expression alone had no effect on amylose content; however, suppression of both SBEIIa and SBEIIb expression resulted in starch containing >70% amylose. When the >70% amylose wheat grain was fed to rats in a diet as a wholemeal, several indices of large-bowel function, including short-chain fatty acids, were improved relative to standard wholemeal wheat. These results indicate that this high-amylose wheat has a significant potential to improve human health through its resistant starch content.Entities:
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Year: 2006 PMID： 16537443 PMCID： PMC1450120 DOI： 10.1073/pnas.0510737103
Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205