| Literature DB >> 16537084 |
Randolph V Clower1, Yan Hu, Thomas Melendy.
Abstract
The papillomavirus (PV) E2 protein plays a role in recruiting viral and cellular DNA replication factors, such as PV E1 or RPA to PV genomes. Using both purified proteins and through co-precipitation, it was determined that HPV-11 E2 binds human topoisomerase I. E2 can stimulate topoisomerase I DNA relaxation activity 3- to 4-fold. Conversely, topoisomerase I is unable to stimulate E2 DNA binding. These findings suggest that stimulation of topoisomerase I by E2 may help promote efficient relaxation of the torsional stress induced by PV DNA replication.Entities:
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Year: 2006 PMID： 16537084 DOI： 10.1016/j.virol.2006.02.018
Source DB: PubMed Journal: Virology ISSN： 0042-6822 Impact factor: 3.616