Literature DB >> 16536962

Genetic epidemiology and primary care.

Blair H Smith1, Graham C M Watt, Harry Campbell, Aziz Sheikh.   

Abstract

Large-scale, population-based studies of genetic epidemiology are under way or planned in several countries, including the UK. The results will have many implications for GPs and their patients. Primary care has much to contribute to this research, and basing genetic epidemiology studies in primary care will confer several advantages. These include enhanced public engagement, building on the personal relationships and trust that are at the core of primary care practice; methodological factors that will strengthen study design; and the potential of linkage of multiple datasets and between networks of research practices. Essential development work with primary care professionals and the public is, however, required for this to happen, and, if undertaken, this work will have the additional important benefit of increasing the uptake of new knowledge into general practice.

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Year:  2006        PMID: 16536962      PMCID: PMC1828265     

Source DB:  PubMed          Journal:  Br J Gen Pract        ISSN: 0960-1643            Impact factor:   5.386


  51 in total

1.  What will the new genetic information do for us?

Authors:  Graham Watt
Journal:  J Health Serv Res Policy       Date:  2004-07

Review 2.  The emergence of epidemiology in the genomics age.

Authors:  Muin J Khoury; Robert Millikan; Julian Little; Marta Gwinn
Journal:  Int J Epidemiol       Date:  2004-08-19       Impact factor: 7.196

Review 3.  Timeline: Raising the profile of genetics in primary care.

Authors:  Nadeem Qureshi; Bernadette Modell; Michael Modell
Journal:  Nat Rev Genet       Date:  2004-10       Impact factor: 53.242

4.  Factors affecting the level of interest and activity in primary care research among general practitioners.

Authors:  C A Silagy; N E Carson
Journal:  Fam Pract       Date:  1989-09       Impact factor: 2.267

5.  Identification of the breast cancer susceptibility gene BRCA2.

Authors:  R Wooster; G Bignell; J Lancaster; S Swift; S Seal; J Mangion; N Collins; S Gregory; C Gumbs; G Micklem
Journal:  Nature       Date:  1995 Dec 21-28       Impact factor: 49.962

6.  A strong candidate for the breast and ovarian cancer susceptibility gene BRCA1.

Authors:  Y Miki; J Swensen; D Shattuck-Eidens; P A Futreal; K Harshman; S Tavtigian; Q Liu; C Cochran; L M Bennett; W Ding
Journal:  Science       Date:  1994-10-07       Impact factor: 47.728

7.  Genetic variation in dopaminergic pathways and short-term effectiveness of the nicotine patch.

Authors:  Elaine C Johnstone; Patricia L Yudkin; Kate Hey; Sarah J Roberts; Sarah J Welch; Michael F Murphy; Siân E Griffiths; Robert T Walton
Journal:  Pharmacogenetics       Date:  2004-02

8.  Genetic linkage analysis in familial breast and ovarian cancer: results from 214 families. The Breast Cancer Linkage Consortium.

Authors:  D F Easton; D T Bishop; D Ford; G P Crockford
Journal:  Am J Hum Genet       Date:  1993-04       Impact factor: 11.025

9.  Effectiveness of nicotine patches in relation to genotype in women versus men: randomised controlled trial.

Authors:  Patricia Yudkin; Marcus Munafò; Kate Hey; Sarah Roberts; Sarah Welch; Elaine Johnstone; Michael Murphy; Siân Griffiths; Robert Walton
Journal:  BMJ       Date:  2004-03-19

10.  Genetic analysis of breast cancer in the cancer and steroid hormone study.

Authors:  E B Claus; N Risch; W D Thompson
Journal:  Am J Hum Genet       Date:  1991-02       Impact factor: 11.025

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  6 in total

1.  Academic health sciences centres: an opportunity to improve services, teaching, and research.

Authors:  Brendan Delaney; John Moxham; Robert Lechler
Journal:  Br J Gen Pract       Date:  2010-10       Impact factor: 5.386

2.  Genetic epidemiology and primary care.

Authors:  Michael H Draisey
Journal:  Br J Gen Pract       Date:  2006-05       Impact factor: 5.386

3.  Genetics, Big Brother and the GP.

Authors:  Tom Shakespeare
Journal:  Br J Gen Pract       Date:  2006-03       Impact factor: 5.386

4.  Community engagement about genetic variation research.

Authors:  Sharon F Terry; Kurt D Christensen; Susan Metosky; Gayle Rudofsky; Kathleen P Deignan; Hulda Martinez; Penelope Johnson-Moore; Toby Citrin
Journal:  Popul Health Manag       Date:  2011-08-04       Impact factor: 2.459

5.  Generation Scotland: the Scottish Family Health Study; a new resource for researching genes and heritability.

Authors:  Blair H Smith; Harry Campbell; Douglas Blackwood; John Connell; Mike Connor; Ian J Deary; Anna F Dominiczak; Bridie Fitzpatrick; Ian Ford; Cathy Jackson; Gillian Haddow; Shona Kerr; Robert Lindsay; Mark McGilchrist; Robin Morton; Graeme Murray; Colin N A Palmer; Jill P Pell; Stuart H Ralston; David St Clair; Frank Sullivan; Graham Watt; Roland Wolf; Alan Wright; David Porteous; Andrew D Morris
Journal:  BMC Med Genet       Date:  2006-10-02       Impact factor: 2.103

6.  Incorporating ethnicity into genetic risk assessment for Alzheimer disease: the REVEAL study experience.

Authors:  Kurt D Christensen; J Scott Roberts; Charmaine D M Royal; Grace-Ann Fasaye; Thomas Obisesan; L Adrienne Cupples; Peter J Whitehouse; Melissa Barber Butson; Erin Linnenbringer; Norman R Relkin; Lindsay Farrer; Robert Cook-Deegan; Robert C Green
Journal:  Genet Med       Date:  2008-03       Impact factor: 8.822

  6 in total

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