Literature DB >> 16533715

The impact of microwave-assisted organic synthesis in drug discovery.

Farah Mavandadi1, Ake Pilotti.   

Abstract

Microwave-assisted organic synthesis has revolutionized organic synthesis. Small molecules can be built in a fraction of the time required by classical thermal methods. As a result, this technique has rapidly gained acceptance as a valuable tool for accelerating drug discovery and development processes. This article outlines the basic principles behind microwave technology and summarizes recent trends and areas in drug discovery where this technology has made an impact.

Mesh:

Substances:

Year:  2006        PMID: 16533715     DOI: 10.1016/S1359-6446(05)03695-0

Source DB:  PubMed          Journal:  Drug Discov Today        ISSN: 1359-6446            Impact factor:   7.851


  14 in total

Review 1.  Controlled microwave heating in modern organic synthesis: highlights from the 2004-2008 literature.

Authors:  C Oliver Kappe; Doris Dallinger
Journal:  Mol Divers       Date:  2009-04-21       Impact factor: 2.943

2.  Chemistry and pharmacological characterization of novel nitrogen analogues of AMOP-H-OH (Sazetidine-A, 6-[5-(azetidin-2-ylmethoxy)pyridin-3-yl]hex-5-yn-1-ol) as α4β2-nicotinic acetylcholine receptor-selective partial agonists.

Authors:  Jianhua Liu; J Brek Eaton; Barbara Caldarone; Ronald J Lukas; Alan P Kozikowski
Journal:  J Med Chem       Date:  2010-10-14       Impact factor: 7.446

3.  Microwave-Assisted Direct Biaryl Coupling: First Application to the Synthesis of Aporphines.

Authors:  Sandeep Chaudhary; Stevan Pecic; Onica Legendre; Wayne W Harding
Journal:  Tetrahedron Lett       Date:  2009-05-20       Impact factor: 2.415

4.  Synthesis and Hypoglycemic and Anti-inflammatory Activity Screening of Novel Substituted 5-[Morpholino(Phenyl)Methyl]-Thiazolidine-2,4-Diones and Their Molecular Docking Studies.

Authors:  Srikanth Kumar Karumanchi; Lakshmana Rao Atmakuri; V Basaveswara Rao Mandava; Srikala Rajala
Journal:  Turk J Pharm Sci       Date:  2019-11-11

5.  Optimization of forced degradation using experimental design and development of a stability-indicating liquid chromatographic assay method for rebamipide in bulk and tablet dosage form.

Authors:  Sandeep Sonawane; Paraag Gide
Journal:  Sci Pharm       Date:  2011-01-10

6.  Microwave-Assisted Synthesis of a MK2 Inhibitor by Suzuki-Miyaura Coupling for Study in Werner Syndrome Cells.

Authors:  Mark C Bagley; Mohammed Baashen; Irina Chuckowree; Jessica E Dwyer; David Kipling; Terence Davis
Journal:  Pharmaceuticals (Basel)       Date:  2015-06-03

7.  Novel microwave-assisted synthesis of the immunomodulator organotellurium compound ammonium trichloro(dioxoethylene-O,O')tellurate (AS101).

Authors:  M Pilar Vázquez-Tato; Alberto Mena-Menéndez; Xesús Feás; Julio A Seijas
Journal:  Int J Mol Sci       Date:  2014-02-21       Impact factor: 5.923

8.  Comparison of Conventional and Microwave-assisted Synthesis of Benzotriazole Derivatives.

Authors:  J J Shah; Krishnapriya Mohanraj
Journal:  Indian J Pharm Sci       Date:  2014-01       Impact factor: 0.975

9.  Synthesis of gamma-nitro aliphatic methyl esters via Michael additions promoted by microwave irradiation.

Authors:  Jaime Escalante; Francisco D Díaz-Coutiño
Journal:  Molecules       Date:  2009-04-21       Impact factor: 4.411

10.  Design, synthesis, biological evaluation and molecular docking studies of novel 3-substituted-5-[(indol-3-yl)methylene]-thiazolidine-2,4-dione derivatives.

Authors:  K Srikanth Kumar; A Lakshmana Rao; M V Basaveswara Rao
Journal:  Heliyon       Date:  2018-09-20
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.