Literature DB >> 1653367

Inhibition of mouse T-cell proliferation by CGRP and VIP: effects of these neuropeptides on IL-2 production and cAMP synthesis.

F Boudard1, M Bastide.   

Abstract

We compared the effect of two neuropeptides, calcitonin gene-related peptide (CGRP) and vasoactive intestinal peptide (VIP), on mitogen-induced murine splenocyte proliferation. Both neuropeptides exerted their maximal effect within 24 hr after activation by Con A. The combination CGRP-VIP caused an additive inhibitory effect on T-cell proliferation. The inhibitory effect of VIP could be correlated with a decrease in interleukin 2 (IL-2) production, whereas CGRP did not affect this production. Since we also observed an additive inhibitory effect on T-cell proliferation by the theophylline and CGRP or VIP combination, we measured the effect of each neuropeptide on intracellular cAMP production by enriched T-cells: CGRP, but not VIP, strongly stimulated cAMP synthesis. Taken together, our results indicate that inhibition of murine T-cell proliferation by CGRP and VIP is mediated by different mechanisms.

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Year:  1991        PMID： 1653367     DOI： 10.1002/jnr.490290104

Source DB:  PubMed          Journal:  J Neurosci Res        ISSN： 0360-4012            Impact factor:   4.164


  10 in total

1.  Administration of a vasoactive intestinal peptide antagonist enhances the autologous anti-leukemia T cell response in murine models of acute leukemia.

Authors:  Christopher T Petersen; Jian-Ming Li; Edmund K Waller
Journal:  Oncoimmunology       Date:  2017-03-16       Impact factor: 8.110

2.  Rat-2 fibroblasts express specific adrenomedullin receptors, but not calcitonin-gene-related-peptide receptors, which mediate increased intracellular cAMP and inhibit mitogen-activated protein kinase activity.

Authors:  H A Coppock; A A Owji; C Austin; P D Upton; M L Jackson; J V Gardiner; M A Ghatei; S R Bloom; D M Smith
Journal:  Biochem J       Date:  1999-02-15       Impact factor: 3.857

3.  Predominant expression of type II vasoactive intestinal peptide receptors by human T lymphoblastoma cells: transduction of both Ca2+ and cyclic AMP signals.

Authors:  M Xia; S P Sreedharan; E J Goetzl
Journal:  J Clin Immunol       Date:  1996-01       Impact factor: 8.317

4.  Vasoactive intestinal peptide and pituitary adenylyl cyclase-activating polypeptide inhibit tumor necrosis factor-alpha production in injured spinal cord and in activated microglia via a cAMP-dependent pathway.

Authors:  W K Kim; Y Kan; D Ganea; R P Hart; I Gozes; G M Jonakait
Journal:  J Neurosci       Date:  2000-05-15       Impact factor: 6.167

Review 5.  Neural Immune Communication in the Control of Host-Bacterial Pathogen Interactions in the Gastrointestinal Tract.

Authors:  Valerie Ramirez; Samantha Swain; Kaitlin Murray; Colin Reardon
Journal:  Infect Immun       Date:  2020-08-19       Impact factor: 3.441

Review 6.  VIP as a cell-growth and differentiation neuromodulator role in neurodevelopment.

Authors:  J M Muller; V Lelievre; L Becq-Giraudon; A C Meunier
Journal:  Mol Neurobiol       Date:  1995 Apr-Jun       Impact factor: 5.590

7.  Neuropeptide CGRP Limits Group 2 Innate Lymphoid Cell Responses and Constrains Type 2 Inflammation.

Authors:  Hiroyuki Nagashima; Tanel Mahlakõiv; Han-Yu Shih; Fred P Davis; Francoise Meylan; Yuefeng Huang; Oliver J Harrison; Chen Yao; Yohei Mikami; Joseph F Urban; Kathleen M Caron; Yasmine Belkaid; Yuka Kanno; David Artis; John J O'Shea
Journal:  Immunity       Date:  2019-07-25       Impact factor: 31.745

8.  Improving T-cell expansion and function for adoptive T-cell therapy using ex vivo treatment with PI3Kδ inhibitors and VIP antagonists.

Authors:  Christopher T Petersen; Mojibade Hassan; Anna B Morris; Jasmin Jeffery; Kunhee Lee; Neera Jagirdar; Ashley D Staton; Sunil S Raikar; Harold T Spencer; Todd Sulchek; Christopher R Flowers; Edmund K Waller
Journal:  Blood Adv       Date:  2018-02-13

9.  Regulation of lymphocyte calcitonin receptors by interleukin-1 and interleukin-6.

Authors:  J J Body; G Fernandez; M Lacroix; P Vandenbussche; J Content
Journal:  Calcif Tissue Int       Date:  1994-08       Impact factor: 4.333

10.  Superior Cervical Ganglia Neurons Induce Foxp3+ Regulatory T Cells via Calcitonin Gene-Related Peptide.

Authors:  Kirsten Szklany; Evelyn Ruiter; Firoz Mian; Wolfgang Kunze; John Bienenstock; Paul Forsythe; Khalil Karimi
Journal:  PLoS One       Date:  2016-03-29       Impact factor: 3.240
  10 in total

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