Literature DB >> 16532306

Drug transporters in pharmacokinetics.

Ernst Petzinger1, Joachim Geyer.   

Abstract

This review deals with the drug transporters allowing drugs to enter and leave cells by carrier-mediated pathways. Emphasis is put on liver transporters but systems in gut, kidney, and blood-brain barrier are mentioned as well. Drug-drug interactions on carriers may provoke significant modification in pharmacokinetics as do carrier gene polymorphisms yielding functional carrier protein mutations. An integrated phase concept should reflect the interplay between drug metabolism and drug transport.

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Year:  2006        PMID： 16532306     DOI： 10.1007/s00210-006-0042-9

Source DB:  PubMed          Journal:  Naunyn Schmiedebergs Arch Pharmacol        ISSN： 0028-1298            Impact factor:   3.000


  137 in total

1.  Catalog of 258 single-nucleotide polymorphisms (SNPs) in genes encoding three organic anion transporters, three organic anion-transporting polypeptides, and three NADH:ubiquinone oxidoreductase flavoproteins.

Authors:  A Iida; S Saito; A Sekine; C Mishima; K Kondo; Y Kitamura; S Harigae; S Osawa; Y Nakamura
Journal:  J Hum Genet       Date:  2001       Impact factor: 3.172

Review 2.  Pharmacogenomics of human OATP transporters.

Authors:  Jörg König; Annick Seithel; Ulrike Gradhand; Martin F Fromm
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2006-03-09       Impact factor: 3.000

Review 3.  Prediction of pharmacokinetic alterations caused by drug-drug interactions: metabolic interaction in the liver.

Authors:  K Ito; T Iwatsubo; S Kanamitsu; K Ueda; H Suzuki; Y Sugiyama
Journal:  Pharmacol Rev       Date:  1998-09       Impact factor: 25.468

Review 4.  Transcriptional regulation of hepatobiliary transport systems in health and disease: implications for a rationale approach to the treatment of intrahepatic cholestasis.

Authors:  Martin Wagner; Michael Trauner
Journal:  Ann Hepatol       Date:  2005 Apr-Jun       Impact factor: 2.400

Review 5.  Toxicological relevance of the multidrug resistance protein 1, MRP1 (ABCC1) and related transporters.

Authors:  E M Leslie; R G Deeley; S P Cole
Journal:  Toxicology       Date:  2001-10-05       Impact factor: 4.221

6.  Acute effects of pravastatin on cholesterol synthesis are associated with SLCO1B1 (encoding OATP1B1) haplotype *17.

Authors:  Mikko Niemi; Pertti J Neuvonen; Ute Hofmann; Janne T Backman; Matthias Schwab; Dieter Lütjohann; Klaus von Bergmann; Michel Eichelbaum; Kari T Kivistö
Journal:  Pharmacogenet Genomics       Date:  2005-05       Impact factor: 2.089

7.  Changes in the localization of the rat canalicular conjugate export pump Mrp2 in phalloidin-induced cholestasis.

Authors:  D Rost; J Kartenbeck; D Keppler
Journal:  Hepatology       Date:  1999-03       Impact factor: 17.425

Review 8.  Hepatobiliary transport.

Authors:  G A Kullak-Ublick; U Beuers; G Paumgartner
Journal:  J Hepatol       Date:  2000       Impact factor: 25.083

9.  A novel human hepatic organic anion transporting polypeptide (OATP2). Identification of a liver-specific human organic anion transporting polypeptide and identification of rat and human hydroxymethylglutaryl-CoA reductase inhibitor transporters.

Authors:  B Hsiang; Y Zhu; Z Wang; Y Wu; V Sasseville; W P Yang; T G Kirchgessner
Journal:  J Biol Chem       Date:  1999-12-24       Impact factor: 5.157

10.  MDR1-deficient genotype in Collie dogs hypersensitive to the P-glycoprotein substrate ivermectin.

Authors:  Alain Roulet; Olivier Puel; Stéphane Gesta; Jean-François Lepage; Marlene Drag; Mark Soll; Michel Alvinerie; Thierry Pineau
Journal:  Eur J Pharmacol       Date:  2003-01-24       Impact factor: 4.432
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  15 in total

1.  A multi-faceted world of transporters.

Authors:  Ernst Petzinger; Gerhard Burckhardt; Robert Tampé
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2006-03       Impact factor: 3.000

2.  How we have learned about the complexity of physiology, pathobiology and pharmacology of bile acids and biliary secretion.

Authors:  Jose J G Marin
Journal:  World J Gastroenterol       Date:  2008-10-07       Impact factor: 5.742

3.  Binding and inhibition of drug transport proteins by heparin: a potential drug transporter modulator capable of reducing multidrug resistance in human cancer cells.

Authors:  Yunliang Chen; Michael Scully; Gloria Petralia; Ajay Kakkar
Journal:  Cancer Biol Ther       Date:  2013-11-19       Impact factor: 4.742

Review 4.  Pharmacogenomics of drug transporters for antiretroviral long-acting pre-exposure prophylaxis for HIV.

Authors:  Nomusa M Zondo; Parveen Sobia; Aida Sivro; Sinaye Ngcapu; Veron Ramsuran; Derseree Archary
Journal:  Front Genet       Date:  2022-09-29       Impact factor: 4.772

Review 5.  Recent progresses in the experimental methods and evaluation strategies of transporter functions for the prediction of the pharmacokinetics in humans.

Authors:  Satoshi Kitamura; Kazuya Maeda; Yuichi Sugiyama
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  2008-06-07       Impact factor: 3.000

6.  Characterization of substrates and inhibitors for the in vitro assessment of Bcrp mediated drug-drug interactions.

Authors:  Uwe Muenster; Birgit Grieshop; Karsten Ickenroth; Mark Jean Gnoth
Journal:  Pharm Res       Date:  2008-06-04       Impact factor: 4.200

Review 7.  Uraemic syndrome of chronic kidney disease: altered remote sensing and signalling.

Authors:  Sanjay K Nigam; Kevin T Bush
Journal:  Nat Rev Nephrol       Date:  2019-05       Impact factor: 28.314

8.  A study of structure-activity relationship and anion-controlled quinolinyl Ag(I) complexes as antimicrobial and antioxidant agents as well as their interaction with macromolecules.

Authors:  Adesola A Adeleke; Sizwe J Zamisa; Md Shahidul Islam; Kolawole Olofinsan; Veronica F Salau; Chunderika Mocktar; Bernard Omondi
Journal:  Biometals       Date:  2022-03-11       Impact factor: 2.949

9.  Membrane transporters for sulfated steroids in the human testis--cellular localization, expression pattern and functional analysis.

Authors:  Daniela Fietz; Katharina Bakhaus; Britta Wapelhorst; Gary Grosser; Sabine Günther; Jörg Alber; Barbara Döring; Sabine Kliesch; Wolfgang Weidner; Christina E Galuska; Michaela F Hartmann; Stefan A Wudy; Martin Bergmann; Joachim Geyer
Journal:  PLoS One       Date:  2013-05-08       Impact factor: 3.240

10.  The Structure and Mechanism of Drug Transporters.

Authors:  Arthur G Roberts
Journal:  Methods Mol Biol       Date:  2021
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