Literature DB >> 16531271

Characterization of the t(17;19) translocation by gene-specific fluorescent in situ hybridization-based cytogenetics and detection of the E2A-HLF fusion transcript and protein in patients' cells.

Jenny Yeung, Helena Kempski, Michael Neat, Simon Bailey, Owen Smith, Hugh J M Brady.   

Abstract

This is the first report to comprehensively characterize the E2A-HLF fusion generated from the t(17;19)(q22;p13) translocation in childhood B-lineage acute lymphoblastic leukemia. E2A gene rearrangement and E2A-HLF transcript and protein expression were determined using conventional cytogenetics, fluorescent in situ hybridization, reverse transcriptase polymerase chain reaction and Western blotting in leukemic cells from three patients.

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Year:  2006        PMID： 16531271

Source DB:  PubMed          Journal:  Haematologica        ISSN： 0390-6078            Impact factor:   9.941


  3 in total

1.  In vitro sensitivity to dasatinib in lymphoblasts from a patient with t(17;19)(q22;p13) gene rearrangement pre-B acute lymphoblastic leukemia.

Authors:  Jason M Glover; Marc Loriaux; Jeffrey W Tyner; Brian J Druker; Bill H Chang
Journal:  Pediatr Blood Cancer       Date:  2011-10-28       Impact factor: 3.167

2.  Hypercalcaemia with disseminated osteolytic lesions: a rare presentation of childhood acute lymphoblastic leukaemia.

Authors:  Rajitha Lokadasan; Shruti Prem; Sumod Mathew Koshy; A V Jayasudha
Journal:  Ecancermedicalscience       Date:  2015-05-26

3.  t(17;19) in Children with Acute Lymphocytic Leukemia: A Report of 3 Cases and a Review of the Literature.

Authors:  Katherine A Minson; Pinki Prasad; Susan Vear; Scott Borinstein; Richard Ho; Jennifer Domm; Haydar Frangoul
Journal:  Case Rep Hematol       Date:  2013-01-03
  3 in total

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