Kenny A Rodriguez-Macias1, Lars Lind, Tord Naessen. 1. Department of Women's and Children's Health, Section for Obstetrics and Gynecology, University Hospital, Uppsala SE-751 85, Sweden.
Abstract
BACKGROUND: The thickness of the arterial intima increases and that of the media decreases with increasing age and degree of atherosclerosis. Separate estimates of the individual intima and media layers might therefore be more appropriate than the commonly used method estimating the combined intima-media thickness (IMT). METHODS AND RESULTS: One hundred consecutive 70-year-old subjects from the PIVUS study were investigated. Separate estimates of the thickness of the carotid artery intima and media wall layers were carried out noninvasively using 25MHz high-frequency ultrasound. Subjects with a diagnosis of cardiovascular disease (CVD), coronary heart disease (CHD), myocardial infarction (MI) or stroke had a significantly thicker intima layer (all P<0.0001) and a thinner media layer (all P<0.05) than healthy subjects. The intima/media thickness ratio also differed significantly between subjects with and without a diagnosis of CVD (0.43+/-0.20versus 0.75+/-0.48, P=0.0002). Subjects with hypertension or hyperlipidemia also had a thicker carotid intima than subjects without these diagnoses (P<0.0005 for both). None of the corresponding intima+media thickness values differed significantly. Similar results were obtained in women and men. CONCLUSION: Separate assessment of carotid artery intima and media thickness using noninvasive high-frequency ultrasound appears to be of potential value, as a striking difference in intima thickness and the intima/media thickness ratio was found between subjects with and without CVD.
BACKGROUND: The thickness of the arterial intima increases and that of the media decreases with increasing age and degree of atherosclerosis. Separate estimates of the individual intima and media layers might therefore be more appropriate than the commonly used method estimating the combined intima-media thickness (IMT). METHODS AND RESULTS: One hundred consecutive 70-year-old subjects from the PIVUS study were investigated. Separate estimates of the thickness of the carotid artery intima and media wall layers were carried out noninvasively using 25MHz high-frequency ultrasound. Subjects with a diagnosis of cardiovascular disease (CVD), coronary heart disease (CHD), myocardial infarction (MI) or stroke had a significantly thicker intima layer (all P<0.0001) and a thinner media layer (all P<0.05) than healthy subjects. The intima/media thickness ratio also differed significantly between subjects with and without a diagnosis of CVD (0.43+/-0.20versus 0.75+/-0.48, P=0.0002). Subjects with hypertension or hyperlipidemia also had a thicker carotid intima than subjects without these diagnoses (P<0.0005 for both). None of the corresponding intima+media thickness values differed significantly. Similar results were obtained in women and men. CONCLUSION: Separate assessment of carotid artery intima and media thickness using noninvasive high-frequency ultrasound appears to be of potential value, as a striking difference in intima thickness and the intima/media thickness ratio was found between subjects with and without CVD.
Authors: Matthias W Lorenz; Joseph F Polak; Maryam Kavousi; Ellisiv B Mathiesen; Henry Völzke; Tomi-Pekka Tuomainen; Dirk Sander; Matthieu Plichart; Alberico L Catapano; Christine M Robertson; Stefan Kiechl; Tatjana Rundek; Moïse Desvarieux; Lars Lind; Caroline Schmid; Pronabesh DasMahapatra; Lu Gao; Kathrin Ziegelbauer; Michiel L Bots; Simon G Thompson Journal: Lancet Date: 2012-04-27 Impact factor: 79.321
Authors: Matthias W Lorenz; Lu Gao; Kathrin Ziegelbauer; Giuseppe Danilo Norata; Jean Philippe Empana; Irene Schmidtmann; Hung-Ju Lin; Stela McLachlan; Lena Bokemark; Kimmo Ronkainen; Mauro Amato; Ulf Schminke; Sathanur R Srinivasan; Lars Lind; Shuhei Okazaki; Coen D A Stehouwer; Peter Willeit; Joseph F Polak; Helmuth Steinmetz; Dirk Sander; Holger Poppert; Moise Desvarieux; M Arfan Ikram; Stein Harald Johnsen; Daniel Staub; Cesare R Sirtori; Bernhard Iglseder; Oscar Beloqui; Gunnar Engström; Alfonso Friera; Francesco Rozza; Wuxiang Xie; Grace Parraga; Liliana Grigore; Matthieu Plichart; Stefan Blankenberg; Ta-Chen Su; Caroline Schmidt; Tomi-Pekka Tuomainen; Fabrizio Veglia; Henry Völzke; Giel Nijpels; Johann Willeit; Ralph L Sacco; Oscar H Franco; Heiko Uthoff; Bo Hedblad; Carmen Suarez; Raffaele Izzo; Dong Zhao; Thapat Wannarong; Alberico Catapano; Pierre Ducimetiere; Christine Espinola-Klein; Kuo-Liong Chien; Jackie F Price; Göran Bergström; Jussi Kauhanen; Elena Tremoli; Marcus Dörr; Gerald Berenson; Kazuo Kitagawa; Jacqueline M Dekker; Stefan Kiechl; Matthias Sitzer; Horst Bickel; Tatjana Rundek; Albert Hofman; Ellisiv B Mathiesen; Samuela Castelnuovo; Manuel F Landecho; Maria Rosvall; Rafael Gabriel; Nicola de Luca; Jing Liu; Damiano Baldassarre; Maryam Kavousi; Eric de Groot; Michiel L Bots; David N Yanez; Simon G Thompson Journal: PLoS One Date: 2018-04-12 Impact factor: 3.240