| Literature DB >> 16530759 |
Kaijin Wu1, Galina V Jerdeva, Silvia R da Costa, Eunbyul Sou, Joel E Schechter, Sarah F Hamm-Alvarez.
Abstract
The acinar epithelial cells of the lacrimal gland are responsible for the production, packaging and regulated exocytosis of tear proteins into ocular surface fluid. This review summarizes new findings on the mechanisms of exocytosis in these cells. Participating proteins are discussed within the context of different categories of trafficking effectors including targeting and specificity factors (rabs, SNAREs) and transport factors (microtubules, actin filaments and motor proteins). Recent information describing fundamental changes in basic exocytotic mechanisms in the NOD mouse, an animal model of Sjögren's syndrome, is presented.Entities:
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Year: 2006 PMID： 16530759 DOI： 10.1016/j.exer.2005.11.009
Source DB: PubMed Journal: Exp Eye Res ISSN： 0014-4835 Impact factor: 3.467