| Literature DB >> 16530492 |
Wei Cao1, Lingyun He, Wenfang Liu, Zhizhuang Huang, Zeneng Cheng.
Abstract
An HPLC-UV method was developed and validated for the determination of AKF-PD in whole blood of rat. Phenacetin was chosen as the internal standard, and the separation was achieved on a C18 column with methanol and 0.02 M phosphate buffer (pH 3.2) as mobile phase. The obtained calibration graphs were linear (r = 0.9999, n = 9) in the range of 0.203-52.0 microg ml(-1). The low limit of quantitation was 0.203 microg ml(-1). This method can be used to study the pharmacokinetics of AKF-PD in rat.Entities:
Mesh：
Substances：
Year: 2006 PMID： 16530492 DOI： 10.1016/j.jchromb.2006.01.010
Source DB: PubMed Journal: J Chromatogr B Analyt Technol Biomed Life Sci ISSN： 1570-0232 Impact factor: 3.205