| Literature DB >> 16530033 |
Abstract
Two papers in this issue of Cell, (Nam et al., 2006; Wilson and Kovall, 2006) report the crystal structure of the Notch transcriptional activation complex. These structures show that the ANK domain of Notch is an integral part of the transcription complex and supports MAM binding, whereas the RAM domain may trigger allosteric changes in the structure needed for the derepression of transcription.Entities:
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Year: 2006 PMID： 16530033 DOI： 10.1016/j.cell.2006.02.028
Source DB: PubMed Journal: Cell ISSN： 0092-8674 Impact factor: 41.582