Literature DB >> 16529974

Efficacy calculation in randomized trials: global or local measures?

Michael Emch1, Mohammad Ali, Camilo Acosta, Mohammad Yunus, David A Sack, John D Clemens.   

Abstract

This study tests whether the effect of a vaccine trial varies in space and why. Analytical z-score maps identify unusually high- and low-efficacy values in a trial area. Relationships between neighborhood efficacy and ecological variables are measured to explain why efficacy varies in space. Efficacy was found to vary regardless of neighborhood size and the variation is related to several ecological determinants. Local efficacy measures can help public health practitioners make better decisions about when and where to vaccinate populations. The concepts offered in this study are pertinent for any health intervention trial, not just vaccines.

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Year:  2006        PMID： 16529974     DOI： 10.1016/j.healthplace.2006.01.005

Source DB:  PubMed          Journal:  Health Place        ISSN： 1353-8292            Impact factor:   4.078


  10 in total

1.  Distance to health services affects local-level vaccine efficacy for pneumococcal conjugate vaccine (PCV) among rural Filipino children.

Authors:  Elisabeth Dowling Root; Marilla Lucero; Hanna Nohynek; Peter Anthamatten; Deborah S K Thomas; Veronica Tallo; Antti Tanskanen; Beatriz P Quiambao; Taneli Puumalainen; Socorro P Lupisan; Petri Ruutu; Erma Ladesma; Gail M Williams; Ian Riley; Eric A F Simões
Journal:  Proc Natl Acad Sci U S A       Date:  2014-02-18       Impact factor: 11.205

2.  Simple sari cloth filtration of water is sustainable and continues to protect villagers from cholera in Matlab, Bangladesh.

Authors:  Anwar Huq; Mohammed Yunus; Syed Salahuddin Sohel; Abbas Bhuiya; Michael Emch; Stephen P Luby; Estelle Russek-Cohen; G Balakrish Nair; R Bradley Sack; Rita R Colwell
Journal:  MBio       Date:  2010-05-18       Impact factor: 7.867

3.  Changing spatial patterns and increasing rurality of HIV prevalence in the Democratic Republic of the Congo between 2007 and 2013.

Authors:  Margaret Carrel; Mark Janko; Melchior Kashamuka Mwandagalirwa; Camille Morgan; Franck Fwamba; Jérémie Muwonga; Antoinette K Tshefu; Steven Meshnick; Michael Emch
Journal:  Health Place       Date:  2016-03-11       Impact factor: 4.078

4.  Spatial and environmental connectivity analysis in a cholera vaccine trial.

Authors:  Michael Emch; Mohammad Ali; Elisabeth D Root; Mohammad Yunus
Journal:  Soc Sci Med       Date:  2009-01-08       Impact factor: 4.634

5.  The role of vaccine coverage within social networks in cholera vaccine efficacy.

Authors:  Elisabeth D Root; Sophia Giebultowicz; Mohammad Ali; Mohammad Yunus; Michael Emch
Journal:  PLoS One       Date:  2011-07-29       Impact factor: 3.240

6.  Geographic Information System and tools of spatial analysis in a pneumococcal vaccine trial.

Authors:  Antti Tanskanen; Leilani T Nillos; Antti Lehtinen; Hanna Nohynek; Diozele Hazel M Sanvictores; Eric Af Simões; Veronica L Tallo; Marilla G Lucero
Journal:  BMC Res Notes       Date:  2012-01-20

7.  The contribution of neighbours to an individual's risk of typhoid outcome.

Authors:  D L Chao; J K Park; F Marks; R L Ochiai; I M Longini; M E Halloran
Journal:  Epidemiol Infect       Date:  2015-05-04       Impact factor: 2.451

8.  Comparative population structure of Plasmodium falciparum circumsporozoite protein NANP repeat lengths in Lilongwe, Malawi.

Authors:  Natalie M Bowman; Seth Congdon; Tisungane Mvalo; Jaymin C Patel; Veronica Escamilla; Michael Emch; Francis Martinson; Irving Hoffman; Steven R Meshnick; Jonathan J Juliano
Journal:  Sci Rep       Date:  2013       Impact factor: 4.379

Review 9.  Challenges in the research and development of new human vaccines.

Authors:  T Barbosa; M Barral-Netto
Journal:  Braz J Med Biol Res       Date:  2013-02       Impact factor: 2.590

Review 10.  Impacts of Ecology, Parasite Antigenic Variation, and Human Genetics on RTS,S/AS01e Malaria Vaccine Efficacy.

Authors:  Griffin J Bell; Selidji Todagbe Agnandji; Kwaku Poku Asante; Anita Ghansah; Portia Kamthunzi; Michael Emch; Jeffrey A Bailey
Journal:  Curr Epidemiol Rep       Date:  2021-07-30
  10 in total

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