| Literature DB >> 16529885 |
Kannan Vivekanandan1, Madugundu Guru Swamy, Sudhanand Prasad, Golak Chandra Maikap, Rama Mukherjee, Anand C Burman.
Abstract
Four different carboplatin injection samples in water ( approximately 10mg/ml) stored at room temperature were investigated for degradation products by electrospray liquid chromatography-mass spectrometry (ESI/LC-MS). A mass spectrometer compatible mobile phase system with 0.02% formic acid and methanol was used to resolve the impurities. Possible chemical structures of the unknown impurities and its degradation mechanism were proposed based on its experimental results and literature findings.Entities:
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Year: 2006 PMID： 16529885 DOI： 10.1016/j.ijpharm.2006.02.002
Source DB: PubMed Journal: Int J Pharm ISSN： 0378-5173 Impact factor: 5.875