[Influence of CO2 pneumoperitoneum on liver function].

CO2 pneumoperitoneum is an insuflication of CO2 into abdominal cavity in order to enable visulation of organs, and easier manipulation with instruments during laparoscopic surgery. Pressure that is being used is between 12 to 20 mmHg, but it is usually 14 mmHG, and it is higher than a pressure in the port system, which is between 7 to 10 mmHG. This causes changes in activity of AST, ALT and bilirubin during the laparoscopic surgery. In this research we have had two groups of 30 patients that had laparoscopic holecystectomy (researched group) and laparoscopic (control group) surgical technique. We have had compared values of activity for AST, ALT and bilirubin before and after the surgeries (after 6, 24, 48 and 72 hours). We concluded that changes of activity for AST, ALT and bilirubin during laparoscopic surgery are more outstanding with higher degree of significance than what happened during laparotomic surgery. Changes are of transitory nature and after 72 hours they return to the preoperative values.