| Literature DB >> 16527321 |
Rong Xu1, Indresh K Srivastava, Larene Kuller, Irina Zarkikh, Zane Kraft, Zahra Fagrouch, Norman L Letvin, Jonathan L Heeney, Susan W Barnett, Leonidas Stamatatos.
Abstract
Immunization by the SF162gp140 or the DeltaV2gp140 HIV-1 envelope proteins results in the generation of strong homologous neutralizing antibodies (NAbs) that offer similar degree of protection from disease-development to macaques challenged with homologous virus. These two immunogens elicit weak cross-reactive NAbs and their effectiveness against heterologous challenge is currently unknown. To examine this issue, we immunized macaques with SIVGag p55 and either the SF162gp140 or the DeltaV2gp140 and challenged them intravenously with SHIV-89.6P. All animals became infected but previous immunization with SF162gp140 accelerated the development of anti-SHIV89.6P neutralizing antibody responses following infection. DeltaV2gp140 is derived from SF162gp140 following the deletion of 30 amino acids and one N-linked glycosylation site from the V2 loop. Our results suggest that even small differences in HIV Envelope immunogen structure can affect the neutralizing antibody responses generated following infection.Entities:
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Year: 2006 PMID： 16527321 DOI： 10.1016/j.virol.2006.01.043
Source DB: PubMed Journal: Virology ISSN： 0042-6822 Impact factor: 3.616