Literature DB >> 16527275

Level of M(IP)2C sphingolipid affects plant defensin sensitivity, oxidative stress resistance and chronological life-span in yeast.

An M Aerts1, Isabelle E J A François, Leen Bammens, Bruno P A Cammue, Bart Smets, Joris Winderickx, Sabina Accardo, Dirk E De Vos, Karin Thevissen.   

Abstract

The antifungal plant defensin DmAMP1 interacts with fungal sphingolipids of mannosyldiinositolphosphorylceramide (M(IP)2C) class. We screened a Saccharomyces cerevisiae transposon (Tn) mutant library against DmAMP1 and identified one DmAMP1-resistant mutant with the Tn inserted in the M(IP)2C biosynthesis gene IPT1 (DmTn11) and one DmAMP1-hypersensitive mutant with the Tn inserted in rDNA (HsTnII). However, tetrad analysis pointed to HsTnII as a spontaneous mutant. Apparently, membranes of DmTn11 lack M(IP)2C, whereas membranes of HsTnII have increased M(IP)2C levels. In addition, DmTn11 and HsTnII are characterized by increased and reduced oxidative stress resistance/chronological life-span (CL), respectively. A putative involvement of M(IP)2C in oxidative stress and CL in yeast is discussed.

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Year:  2006        PMID： 16527275     DOI： 10.1016/j.febslet.2006.02.061

Source DB:  PubMed          Journal:  FEBS Lett        ISSN： 0014-5793            Impact factor:   4.124


  21 in total

1.  Isc1p plays a key role in hydrogen peroxide resistance and chronological lifespan through modulation of iron levels and apoptosis.

Authors:  Teresa Almeida; Marta Marques; Dominik Mojzita; Maria A Amorim; Rui D Silva; Bruno Almeida; Pedro Rodrigues; Paula Ludovico; Stefan Hohmann; Pedro Moradas-Ferreira; Manuela Côrte-Real; Vítor Costa
Journal:  Mol Biol Cell       Date:  2007-12-27       Impact factor: 4.138

Review 2.  Sphingolipids and lifespan regulation.

Authors:  Xinhe Huang; Bradley R Withers; Robert C Dickson
Journal:  Biochim Biophys Acta       Date:  2013-08-15

3.  Activation of protein kinase C-mitogen-activated protein kinase signaling in response to inositol starvation triggers Sir2p-dependent telomeric silencing in yeast.

Authors:  Sojin Lee; Maria L Gaspar; Manuel A Aregullin; Stephen A Jesch; Susan A Henry
Journal:  J Biol Chem       Date:  2013-08-13       Impact factor: 5.157

4.  Interaction of Scots Pine Defensin with Model Membrane by Coarse-Grained Molecular Dynamics.

Authors:  Elena Ermakova; Yuriy Zuev
Journal:  J Membr Biol       Date:  2017-02-18       Impact factor: 1.843

5.  Role for Sit4p-dependent mitochondrial dysfunction in mediating the shortened chronological lifespan and oxidative stress sensitivity of Isc1p-deficient cells.

Authors:  António Daniel Barbosa; Hugo Osório; Kellie J Sims; Teresa Almeida; Mariana Alves; Jacek Bielawski; Maria Amélia Amorim; Pedro Moradas-Ferreira; Yusuf A Hannun; Vítor Costa
Journal:  Mol Microbiol       Date:  2011-06-28       Impact factor: 3.501

6.  The Tomato Defensin TPP3 Binds Phosphatidylinositol (4,5)-Bisphosphate via a Conserved Dimeric Cationic Grip Conformation To Mediate Cell Lysis.

Authors:  Amy A Baxter; Viviane Richter; Fung T Lay; Ivan K H Poon; Christopher G Adda; Prem K Veneer; Thanh Kha Phan; Mark R Bleackley; Marilyn A Anderson; Marc Kvansakul; Mark D Hulett
Journal:  Mol Cell Biol       Date:  2015-03-23       Impact factor: 4.272

Review 7.  Sphingolipids as targets for treatment of fungal infections.

Authors:  Rodrigo Rollin-Pinheiro; Ashutosh Singh; Eliana Barreto-Bergter; Maurizio Del Poeta
Journal:  Future Med Chem       Date:  2016-08-09       Impact factor: 3.808

8.  Vv-AMP1, a ripening induced peptide from Vitis vinifera shows strong antifungal activity.

Authors:  Abré de Beer; Melané A Vivier
Journal:  BMC Plant Biol       Date:  2008-07-08       Impact factor: 4.215

9.  Evolutionary relationship between defensins in the Poaceae family strengthened by the characterization of new sugarcane defensins.

Authors:  V S De-Paula; G Razzera; L Medeiros; C A Miyamoto; M S Almeida; E Kurtenbach; F C L Almeida; A P Valente
Journal:  Plant Mol Biol       Date:  2008-07-12       Impact factor: 4.076

10.  Loss of hydroxyl groups from the ceramide moiety can modify the lateral diffusion of membrane proteins in S. cerevisiae.

Authors:  Satoshi Uemura; Fumi Shishido; Motohiro Tani; Takahiro Mochizuki; Fumiyoshi Abe; Jin-Ichi Inokuchi
Journal:  J Lipid Res       Date:  2014-05-29       Impact factor: 5.922
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