Literature DB >> 1652715

Modulation of neuroeffector transmission in the guinea pig pulmonary artery by endogenous nitric oxide.

B Cederqvist1, N P Wiklund, M G Persson, L E Gustafsson.   

Abstract

The influence of endogenous nitric oxide (NO) on neuroeffector transmission in segments of guinea pig pulmonary artery was analyzed by application of NG-monomethyl-L-arginine (L-NMMA). L-NMMA enhanced contractile responses to nerve stimulation and this enhancement was counteracted by L-arginine. The enhancement remained after removal of the endothelium. L-NMMA enhanced contractions to exogenous noradrenaline. After blockade of adrenergic transmission by phentolamine, L-NMMA enhanced contractions induced by nonadrenergic-noncholinergic (NANC) neurotransmission. Stimulation-induced release of [3H]noradrenaline was unchanged by L-NMMA. The results suggest that endogenous NO exerts a postjunctional inhibition on adrenergic neurotransmission in the guinea pig pulmonary artery. A concomitant pre- and/or postjunctional inhibition of NANC transmission is implicated. The neuromodulation by NO does not require an intact endothelium.

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Year:  1991        PMID： 1652715     DOI： 10.1016/0304-3940(91)90896-2

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  9 in total

1.  Nitrergic control of peripheral sympathetic responses in the human corpus cavernosum: a comparison with other species.

Authors:  S Cellek; S Moncada
Journal:  Proc Natl Acad Sci U S A       Date:  1997-07-22       Impact factor: 11.205

2.  Nitric oxide synthase-immunoreactive axons innervating the guinea-pig lingual artery: an ultrastructural immunohistochemical study using elastic brightfield imaging.

Authors:  W Kummer; B Mayer
Journal:  Histochemistry       Date:  1993-02

3.  Modulation of cholinergic and substance P-like neurotransmission by nitric oxide in the guinea-pig ileum.

Authors:  C U Wiklund; C Olgart; N P Wiklund; L E Gustafsson
Journal:  Br J Pharmacol       Date:  1993-10       Impact factor: 8.739

4.  Chronic blockade of nitric oxide synthesis elevates plasma levels of catecholamines and their metabolites at rest and during stress in rats.

Authors:  R Kvetnanský; K Pacák; D Tokarev; J Jeloková; D Jezová; M Rusnák
Journal:  Neurochem Res       Date:  1997-08       Impact factor: 3.996

Review 5.  Neuronal and non-neuronal modulation of sympathetic neurovascular transmission.

Authors:  H Macarthur; G H Wilken; T C Westfall; L L Kolo
Journal:  Acta Physiol (Oxf)       Date:  2011-03-01       Impact factor: 6.311

6.  Functional relation between nitric oxide and noradrenaline for the modulation of vascular tone in rat mesenteric vasculature.

Authors:  R Yamamoto; A Wada; Y Asada; T Yuhi; T Yanagita; H Niina; A Sumiyoshi
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1994-04       Impact factor: 3.000

7.  N omega-nitro-L-arginine, an inhibitor of nitric oxide synthesis, decreases noradrenaline outflow in rat isolated perfused mesenteric vasculature.

Authors:  R Yamamoto; A Wada; Y Asada; H Niina; A Sumiyoshi
Journal:  Naunyn Schmiedebergs Arch Pharmacol       Date:  1993-02       Impact factor: 3.000

8.  Characterization of nitrergic neurotransmission during short- and long-term electrical stimulation of the rabbit anococcygeus muscle.

Authors:  L Kasakov; S Cellek; S Moncada
Journal:  Br J Pharmacol       Date:  1995-08       Impact factor: 8.739

9.  Noradrenergic-nitrergic interactions in the rat anococcygeus muscle: evidence for postjunctional modulation by nitric oxide.

Authors:  L Kasakov; A Belai; M Vlaskovska; G Burnstock
Journal:  Br J Pharmacol       Date:  1994-06       Impact factor: 8.739
  9 in total

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