Postischemic alteration of [3H]forskolin binding sites in selectively vulnerable areas: an autoradiographic study of gerbil brain.

The postischemic alteration in forskolin receptor binding sites 1 h to 1 month after transient cerebral ischemia was studied in the gerbil. Forskolin binding showed marked reduction in the striatum at an early stage of recirculation, whereas a transient increase was seen in the frontal cortex, the hippocampal regions, and the thalamus. The dentate molecular layer and the parietal cortex revealed no significant changes in the forskolin receptor binding. However, a significant reduction in the forskolin receptor binding was found in these areas after 48 h or 7 days of recirculation. These results suggest that the neuronal damage in the selectively vulnerable areas following transient cerebral ischemia may process with different mechanisms.