| Literature DB >> 16526812 |
K Surendra1, N Srilakshmi Krishnaveni, A Mahesh, K Rama Rao.
Abstract
An environmentally benign and highly efficient procedure for the nucleophilic addition of trimethylsilyl cyanide to imines (Strecker reaction) has been developed under biomimetic conditions in water in the presence of beta-cyclodextrin to afford alpha-aminonitriles in quantitative yields. The use of cyclodextrin precludes the use of either acid or base, and the catalyst can be recycled a number of times without loss in activity.Entities:
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Year: 2006 PMID： 16526812 DOI： 10.1021/jo052510n
Source DB: PubMed Journal: J Org Chem ISSN： 0022-3263 Impact factor: 4.354