Literature DB >> 16525733

Genomic features of attenuated Junín virus vaccine strain candidate.

Sandra Elizabeth Goñi1, Javier Alonso Iserte, Ana Maria Ambrosio, Victor Romanowski, Pablo Daniel Ghiringhelli, Mario Enrique Lozano.   

Abstract

Junin virus strain Candid #1 was developed as a live attenuated vaccine for Argentine haemorrhagic fever. In this paper, we report the nucleotide sequences of L RNA of Candid #1 and examine the relationship to its more virulent ancestors Junin virus XJ#44 and XJ 13 (prototype) and other closely and distantly related arenaviruses. Comparisons of the nucleotide and amino acid sequences of L and Z genes of Candid #1 and its progenitor strains revealed twelve point mutations in the L polypeptide that are unique to the vaccine strain. These changes could be provisionally associated with the attenuated phenotype. In contrast, Z ORF was completely conserved among all strains.

Entities:  

Mesh：

Substances：

Year:  2006        PMID： 16525733     DOI： 10.1007/s11262-005-5843-2

Source DB:  PubMed          Journal:  Virus Genes        ISSN： 0920-8569            Impact factor:   2.332


  17 in total

1.  Application of multiple sequence alignment profiles to improve protein secondary structure prediction.

Authors:  J A Cuff; G J Barton
Journal:  Proteins       Date:  2000-08-15

Review 2.  Arenaviruses: genomic RNAs, transcription, and replication.

Authors:  B J Meyer; J C de la Torre; P J Southern
Journal:  Curr Top Microbiol Immunol       Date:  2002       Impact factor: 4.291

3.  A single amino acid mutation in the PA subunit of the influenza virus RNA polymerase promotes the generation of defective interfering RNAs.

Authors:  Ervin Fodor; Louise J Mingay; Mandy Crow; Tao Deng; George G Brownlee
Journal:  J Virol       Date:  2003-04       Impact factor: 5.103

4.  New insights into the evolutionary relationships between arenaviruses provided by comparative analysis of small and large segment sequences.

Authors:  Rémi N Charrel; Jean Jacques Lemasson; Michael Garbutt; Riad Khelifa; Philippe De Micco; Heinz Feldmann; Xavier de Lamballerie
Journal:  Virology       Date:  2003-12-20       Impact factor: 3.616

5.  Codon substitution mutations at two positions in the L polymerase protein of human parainfluenza virus type 1 yield viruses with a spectrum of attenuation in vivo and increased phenotypic stability in vitro.

Authors:  Josephine M McAuliffe; Sonja R Surman; Jason T Newman; Jeffrey M Riggs; Peter L Collins; Brian R Murphy; Mario H Skiadopoulos
Journal:  J Virol       Date:  2004-02       Impact factor: 5.103

6.  Tomato spotted wilt virus S-segment mRNAs have overlapping 3'-ends containing a predicted stem-loop structure and conserved sequence motif.

Authors:  Ingeborg van Knippenberg; Rob Goldbach; Richard Kormelink
Journal:  Virus Res       Date:  2005-06       Impact factor: 3.303

7.  Phylogenetic analysis of the Arenaviridae: patterns of virus evolution and evidence for cospeciation between arenaviruses and their rodent hosts.

Authors:  M D Bowen; C J Peters; S T Nichol
Journal:  Mol Phylogenet Evol       Date:  1997-12       Impact factor: 4.286

8.  Molecular characterization of attenuated Junin virus strains.

Authors:  C G Albariño; P D Ghiringhelli; D M Posik; M E Lozano; A M Ambrosio; A Sanchez; V Romanowski
Journal:  J Gen Virol       Date:  1997-07       Impact factor: 3.891

9.  Arenavirus nucleocapsid protein displays a transcriptional antitermination activity in vivo.

Authors:  M A Tortorici; C G Albariño; D M Posik; P D Ghiringhelli; M E Lozano; R Rivera Pomar; V Romanowski
Journal:  Virus Res       Date:  2001-01       Impact factor: 3.303

10.  Attenuation of bunyavirus replication by rearrangement of viral coding and noncoding sequences.

Authors:  Anice C Lowen; Amanda Boyd; John K Fazakerley; Richard M Elliott
Journal:  J Virol       Date:  2005-06       Impact factor: 5.103
View more
  24 in total

1.  A Proteomics Survey of Junín Virus Interactions with Human Proteins Reveals Host Factors Required for Arenavirus Replication.

Authors:  Christopher M Ziegler; Philip Eisenhauer; Jamie A Kelly; Loan N Dang; Vedran Beganovic; Emily A Bruce; Benjamin R King; David J Shirley; Marion E Weir; Bryan A Ballif; Jason Botten
Journal:  J Virol       Date:  2018-01-30       Impact factor: 5.103

2.  Novel Arenavirus Entry Inhibitors Discovered by Using a Minigenome Rescue System for High-Throughput Drug Screening.

Authors:  Jessica Y Rathbun; Magali E Droniou; Robert Damoiseaux; Kevin G Haworth; Jill E Henley; Colin M Exline; Hyeryun Choe; Paula M Cannon
Journal:  J Virol       Date:  2015-06-03       Impact factor: 5.103

3.  Toll-like receptor 2-mediated innate immune responses against Junín virus in mice lead to antiviral adaptive immune responses during systemic infection and do not affect viral replication in the brain.

Authors:  Christian D Cuevas; Susan R Ross
Journal:  J Virol       Date:  2014-04-23       Impact factor: 5.103

4.  Molecular analysis of the virulence attenuation process in Junín virus vaccine genealogy.

Authors:  Sandra Elizabeth Goñi; Javier Alonso Iserte; Betina Inés Stephan; Cristina Silvia Borio; Pablo Daniel Ghiringhelli; Mario Enrique Lozano
Journal:  Virus Genes       Date:  2010-02-11       Impact factor: 2.332

5.  The major determinant of attenuation in mice of the Candid1 vaccine for Argentine hemorrhagic fever is located in the G2 glycoprotein transmembrane domain.

Authors:  César G Albariño; Brian H Bird; Ayan K Chakrabarti; Kimberly A Dodd; Mike Flint; Eric Bergeron; David M White; Stuart T Nichol
Journal:  J Virol       Date:  2011-07-27       Impact factor: 5.103

6.  Junin virus infects mouse cells and induces innate immune responses.

Authors:  Christian D Cuevas; Madakasira Lavanya; Enxiu Wang; Susan R Ross
Journal:  J Virol       Date:  2011-08-31       Impact factor: 5.103

7.  Highly Sensitive Assay for Measurement of Arenavirus-cell Attachment.

Authors:  Joseph P Klaus; Jason Botten
Journal:  J Vis Exp       Date:  2016-03-02       Impact factor: 1.355

8.  Junín virus infection of human hematopoietic progenitors impairs in vitro proplatelet formation and platelet release via a bystander effect involving type I IFN signaling.

Authors:  Roberto G Pozner; Agustín E Ure; Carolina Jaquenod de Giusti; Lina P D'Atri; Joseph E Italiano; Oscar Torres; Victor Romanowski; Mirta Schattner; Ricardo M Gómez
Journal:  PLoS Pathog       Date:  2010-04-15       Impact factor: 6.823

9.  Expression and purification of Z protein from Junín virus.

Authors:  S E Goñi; C S Borio; F B Romano; R P Rota; M G Pilloff; J A Iserte; M A Tortorici; B I Stephan; M F Bilen; P D Ghiringhelli; M E Lozano
Journal:  J Biomed Biotechnol       Date:  2010-06-29

10.  Assembly of arenavirus envelope glycoprotein GPC in detergent-soluble membrane microdomains.

Authors:  Sudhakar S Agnihothram; Brooke Dancho; Kenneth W Grant; Mark L Grimes; Douglas S Lyles; Jack H Nunberg
Journal:  J Virol       Date:  2009-07-22       Impact factor: 5.103
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.