Literature DB >> 16525553

5-Arylethynyl-2'-deoxyuridines, compounds active against HSV-1.

Mikhail V Skorobogatyi1, Alexei V Ustinov, Irina A Stepanova, Anna A Pchelintseva, Anna L Petrunina, Valeriya L Andronova, Georgi A Galegov, Andrei D Malakhov, Vladimir A Korshun.   

Abstract

Three new 5-arylethynyl-2'-deoxyuridines containing bulky aryls have been prepared and tested against HSV-1 in Vero cells. The introduction of a substituent in the phenyl group of an inactive compound, 5-phenylethynyl-2'-deoxyuridine, leads to the appearance of anti-HSV properties. The most active compounds are those containing a polycyclic aromatic hydrocarbon residue attached to the 5 position of 2'-deoxyuridine through a rigid triple bond.

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Year:  2006        PMID： 16525553     DOI： 10.1039/b516804j

Source DB:  PubMed          Journal:  Org Biomol Chem        ISSN： 1477-0520            Impact factor:   3.876


  6 in total

1.  Rigid amphipathic fusion inhibitors, small molecule antiviral compounds against enveloped viruses.

Authors:  Mireille R St Vincent; Che C Colpitts; Alexey V Ustinov; Muhammad Muqadas; Michael A Joyce; Nicola L Barsby; Raquel F Epand; Richard M Epand; Stanislav A Khramyshev; Olga A Valueva; Vladimir A Korshun; D Lorne J Tyrrell; Luis M Schang
Journal:  Proc Natl Acad Sci U S A       Date:  2010-09-07       Impact factor: 11.205

2.  Total synthesis of (-)-tubingensin B enabled by the strategic use of an aryne cyclization.

Authors:  Michael A Corsello; Junyong Kim; Neil K Garg
Journal:  Nat Chem       Date:  2017-06-19       Impact factor: 24.427

3.  5-Alkynyl-2'-deoxyuridines: chromatography-free synthesis and cytotoxicity evaluation against human breast cancer cells.

Authors:  Srinivasarao Meneni; Ingo Ott; Craig D Sergeant; Adam Sniady; Ronald Gust; Roman Dembinski
Journal:  Bioorg Med Chem       Date:  2007-02-01       Impact factor: 3.641

4.  5-(Perylen-3-yl)ethynyl-arabino-uridine (aUY11), an arabino-based rigid amphipathic fusion inhibitor, targets virion envelope lipids to inhibit fusion of influenza virus, hepatitis C virus, and other enveloped viruses.

Authors:  Che C Colpitts; Alexey V Ustinov; Raquel F Epand; Richard M Epand; Vladimir A Korshun; Luis M Schang
Journal:  J Virol       Date:  2013-01-02       Impact factor: 5.103

5.  Pyrene-nucleobase conjugates: synthesis, oligonucleotide binding and confocal bioimaging studies.

Authors:  Artur Jabłoński; Yannic Fritz; Hans-Achim Wagenknecht; Rafał Czerwieniec; Tytus Bernaś; Damian Trzybiński; Krzysztof Woźniak; Konrad Kowalski
Journal:  Beilstein J Org Chem       Date:  2017-11-28       Impact factor: 2.883

6.  Ramified derivatives of 5-(perylen-3-ylethynyl)uracil-1-acetic acid and their antiviral properties.

Authors:  Ksenia A Sapozhnikova; Nikita A Slesarchuk; Alexey A Orlov; Evgeny V Khvatov; Eugene V Radchenko; Alexey A Chistov; Alexey V Ustinov; Vladimir A Palyulin; Liubov I Kozlovskaya; Dmitry I Osolodkin; Vladimir A Korshun; Vladimir A Brylev
Journal:  RSC Adv       Date:  2019-08-20       Impact factor: 4.036
  6 in total

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