Literature DB >> 16525193

The development of amyloid beta protein deposits in the aged brain.

Dietmar R Thal1, Estibaliz Capetillo-Zarate, Kelly Del Tredici, Heiko Braak.   

Abstract

The deposition of amyloid beta protein (Abeta) in the human brain and the generation of neurofibrillary tangles are the histopathological hallmarks of Alzheimer's disease. Accumulation of Abeta takes place in senile plaques and in cerebrovascular deposits as a result of an imbalance between Abeta production and clearance. This Review describes the different types of Abeta deposits, which can be distinguished by their morphology and by the hierarchical involvement of distinct areas of the brain in Abeta deposition. The role of intracellular Abeta in Abeta deposition and the mechanism of Abeta toxicity are also discussed.

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Year:  2006        PMID： 16525193     DOI： 10.1126/sageke.2006.6.re1

Source DB:  PubMed          Journal:  Sci Aging Knowledge Environ        ISSN： 1539-6150


  83 in total

1.  Neocortical and hippocampal amyloid-β and tau measures associate with dementia in the oldest-old.

Authors:  John L Robinson; Felix Geser; Maria M Corrada; Daniel J Berlau; Steven E Arnold; Virginia M-Y Lee; Claudia H Kawas; John Q Trojanowski
Journal:  Brain       Date:  2011-11-26       Impact factor: 13.501

Review 2.  Mild cognitive impairment: pathology and mechanisms.

Authors:  Elliott J Mufson; Lester Binder; Scott E Counts; Steven T DeKosky; Leyla de Toledo-Morrell; Stephen D Ginsberg; Milos D Ikonomovic; Sylvia E Perez; Stephen W Scheff
Journal:  Acta Neuropathol       Date:  2011-11-19       Impact factor: 17.088

3.  Object recognition memory and BDNF expression are reduced in young TgCRND8 mice.

Authors:  Beverly M Francis; John Kim; Meredith E Barakat; Stephan Fraenkl; Yeni H Yücel; Shiyong Peng; Bernadeta Michalski; Margaret Fahnestock; Joanne McLaurin; Howard T J Mount
Journal:  Neurobiol Aging       Date:  2010-05-05       Impact factor: 4.673

4.  Initiation and propagation of neurodegeneration.

Authors:  Christian Haass
Journal:  Nat Med       Date:  2010-09-21       Impact factor: 53.440

5.  β-Secretase-1 elevation in aged monkey and Alzheimer's disease human cerebral cortex occurs around the vasculature in partnership with multisystem axon terminal pathogenesis and β-amyloid accumulation.

Authors:  Yan Cai; Kun Xiong; Xue-Mei Zhang; Huaibin Cai; Xue-Gang Luo; Jia-Chun Feng; Richard W Clough; Robert G Struble; Peter R Patrylo; Yaping Chu; Jeffrey H Kordower; Xiao-Xin Yan
Journal:  Eur J Neurosci       Date:  2010-08-18       Impact factor: 3.386

Review 6.  Nonhuman primate models of Alzheimer-like cerebral proteopathy.

Authors:  Eric Heuer; Rebecca F Rosen; Amarallys Cintron; Lary C Walker
Journal:  Curr Pharm Des       Date:  2012       Impact factor: 3.116

7.  MRI measures of temporoparietal regions show differential rates of atrophy during prodromal AD.

Authors:  R S Desikan; B Fischl; H J Cabral; T L Kemper; C R G Guttmann; D Blacker; B T Hyman; M S Albert; R J Killiany
Journal:  Neurology       Date:  2008-07-30       Impact factor: 9.910

8.  Beta amyloid in Alzheimer's disease: increased deposition in brain is reflected in reduced concentration in cerebrospinal fluid.

Authors:  Timo Grimmer; Matthias Riemenschneider; Hans Förstl; Gjermund Henriksen; William E Klunk; Chester A Mathis; Tohru Shiga; Hans-Jürgen Wester; Alexander Kurz; Alexander Drzezga
Journal:  Biol Psychiatry       Date:  2009-03-06       Impact factor: 13.382

Review 9.  Beta-amyloid deposition and the aging brain.

Authors:  Karen M Rodrigue; Kristen M Kennedy; Denise C Park
Journal:  Neuropsychol Rev       Date:  2009-11-12       Impact factor: 7.444

Review 10.  Transgenic Drosophila models of Alzheimer's disease and tauopathies.

Authors:  Kanae Iijima-Ando; Koichi Iijima
Journal:  Brain Struct Funct       Date:  2009-12-05       Impact factor: 3.270
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