J-L Yang1, M T Hannan, P J Russell, P J Crowe. 1. Oncology Research Centre, School of Prince of Wales Hospital, Faculty of Medicine, University of New South Wales, Sydney, NSW, Australia. j.yang@unsw.edu.au
Abstract
AIM: To measure epidermal growth factor receptor (HER1/EGFR) expression in a range of soft tissue sarcoma (STS) patient samples. METHOD: HER1/EGFR expression was examined by immunohistochemistry in archival tissues of 46 STS patients. RESULTS: HER1/EGFR was positively expressed in 36/46 of STS samples distributed among different histological types. The levels of HER1/EGFR in STS tumour tissues in positive samples were higher compared to those in nearby normal tissues. CONCLUSION: HER1/EGFR is significantly expressed in soft tissue sarcomas, which is a finding reflected in other series. The significance of this finding for targeted therapy is as yet unknown.
AIM: To measure epidermal growth factor receptor (HER1/EGFR) expression in a range of soft tissue sarcoma (STS) patient samples. METHOD:HER1/EGFR expression was examined by immunohistochemistry in archival tissues of 46 STS patients. RESULTS:HER1/EGFR was positively expressed in 36/46 of STS samples distributed among different histological types. The levels of HER1/EGFR in STS tumour tissues in positive samples were higher compared to those in nearby normal tissues. CONCLUSION:HER1/EGFR is significantly expressed in soft tissue sarcomas, which is a finding reflected in other series. The significance of this finding for targeted therapy is as yet unknown.
Authors: Kimberley S Samkoe; Brent D Bates; Niki N Tselepidakis; Alisha V DSouza; Jason R Gunn; Dipak B Ramkumar; Keith D Paulsen; Brian W Pogue; Eric R Henderson Journal: J Biomed Opt Date: 2017-12 Impact factor: 3.170
Authors: Kimberley S Samkoe; Hira S Sardar; Brent D Bates; Niki N Tselepidakis; Jason R Gunn; Kevin A Hoffer-Hawlik; Joachim Feldwisch; Brian W Pogue; Keith D Paulsen; Eric R Henderson Journal: J Surg Oncol Date: 2019-04-04 Impact factor: 3.454
Authors: Antonella Borgatti; Joseph S Koopmeiners; Aaron L Sarver; Amber L Winter; Kathleen Stuebner; Deborah Todhunter; Anthony E Rizzardi; Jonathan C Henriksen; Stephen Schmechel; Colleen L Forster; Jong-Hyuk Kim; Jerry Froelich; Jillian Walz; Michael S Henson; Matthew Breen; Kerstin Lindblad-Toh; Felix Oh; Kristy Pilbeam; Jaime F Modiano; Daniel A Vallera Journal: Mol Cancer Ther Date: 2017-02-13 Impact factor: 6.009