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Literature DB >> 1652464

Hemorphins derived from hemoglobin have an inhibitory action on angiotensin converting enzyme activity.

I Lantz¹, E L Glämsta, L Talbäck, F Nyberg.

Abstract

The hemorphins are opioid active peptides, which are enzymatically released from the beta-chain of hemoglobin. In this paper we report an inhibitory effect of these peptides on angiotensin converting enzyme (ACE) activity, known to be involved in blood pressure regulation. The hemorphins were found to be quite stable in tissue extracts containing ACE, and their importance as naturally occurring ACE inhibitors is discussed.

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Year: 1991 PMID： 1652464 DOI： 10.1016/0014-5793(91)80011-q

Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124

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Cited

14 in total

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3. Investigation of the structure-activity relationship in a series of new LVV- and VV-hemorphin-7 analogues designed as potential anticonvulsant agents.

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5. Separation and Characterization of Antioxidative and Angiotensin Converting Enzyme Inhibitory Peptide from Jellyfish Gonad Hydrolysate.

Authors: Qin Zhang; Chengcheng Song; Jun Zhao; Xiaomei Shi; Meiling Sun; Jing Liu; Yinghuan Fu; Wengang Jin; Beiwei Zhu
Journal: Molecules Date: 2018-01-05 Impact factor: 4.411

10. Camel Hemorphins Exhibit a More Potent Angiotensin-I Converting Enzyme Inhibitory Activity than Other Mammalian Hemorphins: An In Silico and In Vitro Study.

Authors: Amanat Ali; Seham Abdullah Rashed Alzeyoudi; Shamma Abdulla Almutawa; Alya Nasir Alnajjar; Yusra Al Dhaheri; Ranjit Vijayan
Journal: Biomolecules Date: 2020-03-23

Hemorphins derived from hemoglobin have an inhibitory action on angiotensin converting enzyme activity.

Review 1. Fragments of functional proteins: role in endocrine regulation.

Review 2. Hemopressin and other bioactive peptides from cytosolic proteins: are these non-classical neuropeptides?

3. Investigation of the structure-activity relationship in a series of new LVV- and VV-hemorphin-7 analogues designed as potential anticonvulsant agents.

4. Can the development of lung fibrosis be prevented after COVID-19 infection?

5. Separation and Characterization of Antioxidative and Angiotensin Converting Enzyme Inhibitory Peptide from Jellyfish Gonad Hydrolysate.

6. Brain-transportable dipeptides across the blood-brain barrier in mice.

7. Positive Modulation of Angiotensin II Type 1 Receptor-Mediated Signaling by LVV-Hemorphin-7.

8. Hemoglobin Reassembly of Antimicrobial Fragments from the Midgut of Triatoma infestans.

Review 9. Hemorphins Targeting G Protein-Coupled Receptors.

10. Camel Hemorphins Exhibit a More Potent Angiotensin-I Converting Enzyme Inhibitory Activity than Other Mammalian Hemorphins: An In Silico and In Vitro Study.