OBJECTIVE: The objective of this study was to determine the time-course of computed tomography (CT) contrast enhancement of an iodinated blood-pool contrast agent. METHODS: Five C57BL/6 mice were anesthetized, imaged at baseline, and given an iodinated blood-pool contrast agent. Micro-CT scans were acquired at 0, 0.25, 0.5, 1, 2, 4, 8, and 24 hours after injection. The mean CT number was determined in a region of interest in 7 organs. RESULTS: The CT contrast enhancement was plotted as a function of time for each organ. We identified an imaging window immediately after injection suitable for visualizing the vascular system and a second imaging window at 24 hours for visualizing liver and spleen. CONCLUSIONS: A single injection of the blood-pool contrast agent can be used for dual-phase investigations of the vasculature (t = 0 hours) and liver (t = 24 hours), which can be applied to studies of liver tumors or disease.
OBJECTIVE: The objective of this study was to determine the time-course of computed tomography (CT) contrast enhancement of an iodinated blood-pool contrast agent. METHODS: Five C57BL/6 mice were anesthetized, imaged at baseline, and given an iodinated blood-pool contrast agent. Micro-CT scans were acquired at 0, 0.25, 0.5, 1, 2, 4, 8, and 24 hours after injection. The mean CT number was determined in a region of interest in 7 organs. RESULTS: The CT contrast enhancement was plotted as a function of time for each organ. We identified an imaging window immediately after injection suitable for visualizing the vascular system and a second imaging window at 24 hours for visualizing liver and spleen. CONCLUSIONS: A single injection of the blood-pool contrast agent can be used for dual-phase investigations of the vasculature (t = 0 hours) and liver (t = 24 hours), which can be applied to studies of liver tumors or disease.
Authors: Inneke Willekens; Tony Lahoutte; Nico Buls; Christian Vanhove; Rudi Deklerck; Axel Bossuyt; Johan de Mey Journal: Mol Imaging Biol Date: 2008-12-06 Impact factor: 3.488
Authors: Arvind Chopra; Liang Shan; W C Eckelman; Kam Leung; Martin Latterner; Stephen H Bryant; Anne Menkens Journal: Mol Imaging Biol Date: 2012-02 Impact factor: 3.488
Authors: Robert E Guldberg; Craig L Duvall; Alexandra Peister; Megan E Oest; Angela S P Lin; Ashley W Palmer; Marc E Levenston Journal: Biomaterials Date: 2008-07-16 Impact factor: 12.479