Literature DB >> 16522789

FoxA2 involvement in suppression of protein C, an outcome predictor in experimental sepsis.

David T Berg1, Bruce Gerlitz, Ganesh R Sharma, Mark A Richardson, Eddie J Stephens, Renee L Grubbs, Kimberly C Holmes, Kelly Fynboe, Dominick Montani, Martin S Cramer, Steven D Engle, Joseph A Jakubowski, Josef G Heuer, Brian W Grinnell.   

Abstract

Low levels of protein C (PC) predict outcome as early as 10 h after insult in a rat polymicrobial sepsis model and were associated with suppression of PC mRNA, upstream transcription factor FoxA2, and cofactor hepatocyte nuclear factor 6 (HNF6). Small interfering RNA suppression of FoxA2 in isolated hepatocytes demonstrated regulation of both its cofactor HNF6 and PC. Our data suggest that reduced FoxA2 may be important in the suppression of PC and resulting poor outcome in sepsis.

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Year:  2006        PMID： 16522789      PMCID： PMC1391958          DOI： 10.1128/CVI.13.3.426-432.2006

Source DB:  PubMed          Journal:  Clin Vaccine Immunol        ISSN： 1556-679X


  30 in total

Review 1.  Recombinant human activated protein C: a system modulator of vascular function for treatment of severe sepsis.

Authors:  B W Grinnell; D Joyce
Journal:  Crit Care Med       Date:  2001-07       Impact factor: 7.598

Review 2.  Recombinant human activated protein C attenuates the inflammatory response in endothelium and monocytes by modulating nuclear factor-kappaB.

Authors:  David E Joyce; Brian W Grinnell
Journal:  Crit Care Med       Date:  2002-05       Impact factor: 7.598

3.  Activated protein C inhibits tumor necrosis factor and macrophage migration inhibitory factor production in monocytes.

Authors:  M Schmidt-Supprian; C Murphy; B While; M Lawler; A Kapurniotu; W Voelter; O Smith; J Bernhagen
Journal:  Eur Cytokine Netw       Date:  2000-09       Impact factor: 2.737

Review 4.  Chemokines in the pathogenesis of liver disease: so many players with poorly defined roles.

Authors:  Kenneth J Simpson; Neil C Henderson; Cynthia L Bone-Larson; Nicholas W Lukacs; Cory M Hogaboam; Steven L Kunkel
Journal:  Clin Sci (Lond)       Date:  2003-01       Impact factor: 6.124

5.  Epidemiology of severe sepsis in the United States: analysis of incidence, outcome, and associated costs of care.

Authors:  D C Angus; W T Linde-Zwirble; J Lidicker; G Clermont; J Carcillo; M R Pinsky
Journal:  Crit Care Med       Date:  2001-07       Impact factor: 7.598

6.  Efficacy and safety of recombinant human activated protein C for severe sepsis.

Authors:  G R Bernard; J L Vincent; P F Laterre; S P LaRosa; J F Dhainaut; A Lopez-Rodriguez; J S Steingrub; G E Garber; J D Helterbrand; E W Ely; C J Fisher
Journal:  N Engl J Med       Date:  2001-03-08       Impact factor: 91.245

Review 7.  Pathophysiology of sepsis.

Authors:  Judith Jacobi
Journal:  Am J Health Syst Pharm       Date:  2002-02-15       Impact factor: 2.637

8.  Insulin inhibits hepatocellular glucose production by utilizing liver-enriched transcriptional inhibitory protein to disrupt the association of CREB-binding protein and RNA polymerase II with the phosphoenolpyruvate carboxykinase gene promoter.

Authors:  David T Duong; Mary E Waltner-Law; Rosalie Sears; Linda Sealy; Daryl K Granner
Journal:  J Biol Chem       Date:  2002-06-17       Impact factor: 5.157

9.  Activation of endothelial cell protease activated receptor 1 by the protein C pathway.

Authors:  Matthias Riewald; Ramona J Petrovan; Aaron Donner; Barbara M Mueller; Wolfram Ruf
Journal:  Science       Date:  2002-06-07       Impact factor: 47.728

10.  Association between hepatocyte nuclear factor 6 (HNF-6) and FoxA2 DNA binding domains stimulates FoxA2 transcriptional activity but inhibits HNF-6 DNA binding.

Authors:  Francisco M Rausa; Yongjun Tan; Robert H Costa
Journal:  Mol Cell Biol       Date:  2003-01       Impact factor: 4.272
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  3 in total

1.  2-Amino-4-(1-piperidine) pyridine exhibits inhibitory effect on colon cancer through suppression of FOXA2 expression.

Authors:  Jieshu Wang; Bo Li; Kun Zhao; Xinyou Su
Journal:  3 Biotech       Date:  2019-10-04       Impact factor: 2.406

2.  Global analysis of in vivo Foxa2-binding sites in mouse adult liver using massively parallel sequencing.

Authors:  Elizabeth D Wederell; Mikhail Bilenky; Rebecca Cullum; Nina Thiessen; Melis Dagpinar; Allen Delaney; Richard Varhol; YongJun Zhao; Thomas Zeng; Bridget Bernier; Matthew Ingham; Martin Hirst; Gordon Robertson; Marco A Marra; Steven Jones; Pamela A Hoodless
Journal:  Nucleic Acids Res       Date:  2008-07-08       Impact factor: 16.971

3.  FOXA2 promotes the proliferation, migration and invasion, and epithelial mesenchymal transition in colon cancer.

Authors:  Baolei Wang; Guangwei Liu; Lei Ding; Jun Zhao; Yun Lu
Journal:  Exp Ther Med       Date:  2018-05-11       Impact factor: 2.447
  3 in total

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