Literature DB >> 16522743

Severe alcohol-induced liver disease and the alcohol dependence syndrome.

Stewart Smith1, Joanna White, Chris Nelson, Marianne Davies, Joanne Lavers, Nick Sheron.   

Abstract

AIMS: To examine the hypothesis that patients who present in the UK to detoxification services differ from patients who present with severe alcohol-induced liver disease (ALD) with respect to severity of dependence on alcohol and other features of their drinking history.
METHODS: Levels of alcohol dependence were assessed in 34 patients with severe ALD, all of whom were cirrhotic, and 34 subjects from a residential alcohol detox centre in Southampton using the Severity of Alcohol Dependence Questionnaire (SADQ). During interview, various aspects of participants' alcohol consumption were recorded, including total monthly consumption, whom they usually drank with and where, and, if applicable, what caused them to start drinking heavily. Social circumstances were also noted, including participants' employment and marital status.
RESULTS: Among ALD patients, 58% scored none/mild on the SADQ, 32% moderate and 9% severe. In contrast, 76% of the detox group were graded severe and 34% moderate (P < 0.001). ALD patients were also significantly older, had lower scores on the Alcohol Use Disorders Identification Test, tended to drink less alcohol, were more likely to be in a stable relationship, were less likely to be unemployed and gave different reasons for starting to drink heavily. The ALD group were most likely to have started drinking heavily for social reasons, whereas subjects in the detox group were most likely to have started drinking heavily as a result of relationship or money problems.
CONCLUSION: Patients attending a liver unit and patients admitted to a detoxification unit were separate but overlapping populations of alcohol misusers. Perhaps these two populations of alcohol misusers are likely to require different approaches for effective detection, intervention and treatment.

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Year:  2006        PMID: 16522743     DOI: 10.1093/alcalc/agl014

Source DB:  PubMed          Journal:  Alcohol Alcohol        ISSN: 0735-0414            Impact factor:   2.826


  6 in total

1.  Effectiveness of a nurse-led alcohol liaison service in a secondary care medical unit.

Authors:  S D Ryder; G P Aithal; M Holmes; M Burrows; N R Wright
Journal:  Clin Med (Lond)       Date:  2010-10       Impact factor: 2.659

2.  Are the opportunities to prevent alcohol related liver deaths in the UK in primary or secondary care? A retrospective clinical review and prospective interview study.

Authors:  Clare Verrill; Stewart Smith; Nick Sheron
Journal:  Subst Abuse Treat Prev Policy       Date:  2006-06-15

3.  Evaluation of work-based screening for early signs of alcohol-related liver disease in hazardous and harmful drinkers: the PrevAIL study.

Authors:  Penny A Cook; Michela Morleo; David Billington; Kevin Sanderson-Shortt; Colin Jones; Mark Gabbay; Nick Sheron; Mark A Bellis; Penelope A Phillips-Howard; Ian T Gilmore
Journal:  BMC Public Health       Date:  2015-06-04       Impact factor: 3.295

4.  Hospital contacts with alcohol problems prior to liver cirrhosis or pancreatitis diagnosis.

Authors:  Gro Askgaard; Søren Neermark; David A Leon; Mette S Kjær; Janne S Tolstrup
Journal:  World J Hepatol       Date:  2017-12-28

5.  Do SADQ and AUDIT identify independent impacts of alcohol abuse - clinical and biochemical markers respectively?

Authors:  R Johnson Pradeep; Andrew M Dhilip; Ashok Mysore
Journal:  Indian J Psychiatry       Date:  2015 Jul-Sep       Impact factor: 1.759

6.  Drinking pattern in persons with alcohol dependence with and without cirrhosis: A hospital-based comparative study.

Authors:  Anil Kakunje; Haridas Kanaradi; Ganesh Pai; Ravichandra Karkal; Dilshana Nafisa; Premchand Chandrasekaran
Journal:  Indian J Psychiatry       Date:  2018 Apr-Jun       Impact factor: 1.759

  6 in total

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