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Literature DB >> 16522184

Predicted and measured disorder in peripherin/rds, a retinal tetraspanin.

Abstract

Vertebrate photoreceptor outer segment (OS) morphogenesis requires peripherin/rds (P/rds). We have characterized this protein's C-terminus and present evidence that suggests it is intrinsically disordered. We propose that structural flexibility may underlie the multifunctionality proposed for this domain previously. The extremely short C-termini present in other tetraspanin family members suggest that intrinsic disorder may also play a role for those proteins.

Entities: Disease Gene

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Year: 2005 PMID： 16522184 PMCID： PMC1398073 DOI： 10.2174/0929866054696217

Source DB: PubMed Journal: Protein Pept Lett ISSN： 0929-8665 Impact factor: 1.890

39 in total

1. Role of adaptor complex AP-3 in targeting wild-type and mutated CD63 to lysosomes.

Authors: Brian A Rous; Barbara J Reaves; Gudrun Ihrke; John A G Briggs; Sally R Gray; David J Stephens; George Banting; J Paul Luzio
Journal: Mol Biol Cell Date: 2002-03 Impact factor: 4.138

2. Structure of the tetraspanin main extracellular domain. A partially conserved fold with a structurally variable domain insertion.

Authors: M Seigneuret; A Delaguillaumie; C Lagaudrière-Gesbert; H Conjeaud
Journal: J Biol Chem Date: 2001-08-01 Impact factor: 5.157

Review 3. Tetraspanins.

Authors: C Boucheix; E Rubinstein
Journal: Cell Mol Life Sci Date: 2001-08 Impact factor: 9.261

Review 4. Intrinsically unstructured proteins: re-assessing the protein structure-function paradigm.

Authors: P E Wright; H J Dyson
Journal: J Mol Biol Date: 1999-10-22 Impact factor: 5.469

5. The cGMP-gated channel and related glutamic acid-rich proteins interact with peripherin-2 at the rim region of rod photoreceptor disc membranes.

Authors: A Poetsch; L L Molday; R S Molday
Journal: J Biol Chem Date: 2001-10-18 Impact factor: 5.157

6. Sequence complexity of disordered protein.

Authors: P Romero; Z Obradovic; X Li; E C Garner; C J Brown; A K Dunker
Journal: Proteins Date: 2001-01-01

7. Folding and subunit assembly of photoreceptor peripherin/rds is mediated by determinants within the extracellular/intradiskal EC2 domain: implications for heterogeneous molecular pathologies.

Authors: A F Goldberg; L M Fales; J B Hurley; N Khattree
Journal: J Biol Chem Date: 2001-09-11 Impact factor: 5.157

8. CD81 extracellular domain 3D structure: insight into the tetraspanin superfamily structural motifs.

Authors: K Kitadokoro; D Bordo; G Galli; R Petracca; F Falugi; S Abrignani; G Grandi; M Bolognesi
Journal: EMBO J Date: 2001-01-15 Impact factor: 11.598

9. A peptide analogue to a fusion domain within photoreceptor peripherin/rds promotes membrane adhesion and depolarization.

Authors: K Boesze-Battaglia; F P Stefano; M Fenner; A A Napoli
Journal: Biochim Biophys Acta Date: 2000-02-15

10. Size-distribution analysis of macromolecules by sedimentation velocity ultracentrifugation and lamm equation modeling.

Authors: P Schuck
Journal: Biophys J Date: 2000-03 Impact factor: 4.033

13 in total

1. In situ visualization of protein interactions in sensory neurons: glutamic acid-rich proteins (GARPs) play differential roles for photoreceptor outer segment scaffolding.

Authors: Linda M Ritter; Nidhi Khattree; Beatrice Tam; Orson L Moritz; Frank Schmitz; Andrew F X Goldberg
Journal: J Neurosci Date: 2011-08-03 Impact factor: 6.167

2. An inducible amphipathic helix within the intrinsically disordered C terminus can participate in membrane curvature generation by peripherin-2/rds.

Authors: Michelle L Milstein; Victoria A Kimler; Chiranjib Ghatak; Alexey S Ladokhin; Andrew F X Goldberg
Journal: J Biol Chem Date: 2017-03-21 Impact factor: 5.157

3. Peripherin/rds co-distributes with putative binding partners in basal rod outer segment disks.

Authors: Thomas C Edrington; Maxim Sokolov; Kathleen Boesze-Battaglia
Journal: Exp Eye Res Date: 2011-04-01 Impact factor: 3.467

4. Varying the GARP2-to-RDS Ratio Leads to Defects in Rim Formation and Rod and Cone Function.

Authors: Dibyendu Chakraborty; Shannon M Conley; Marci L DeRamus; Steven J Pittler; Muna I Naash
Journal: Invest Ophthalmol Vis Sci Date: 2015-12 Impact factor: 4.799

5. Membrane curvature generation by a C-terminal amphipathic helix in peripherin-2/rds, a tetraspanin required for photoreceptor sensory cilium morphogenesis.

Authors: Nidhi Khattree; Linda M Ritter; Andrew F X Goldberg
Journal: J Cell Sci Date: 2013-07-25 Impact factor: 5.285

6. The tetraspanin protein peripherin-2 forms a complex with melanoregulin, a putative membrane fusion regulator.

Authors: Kathleen Boesze-Battaglia; Hongman Song; Maxim Sokolov; Concepcion Lillo; Lisa Pankoski-Walker; Cheryl Gretzula; Bridget Gallagher; Rivka A Rachel; Nancy A Jenkins; Neal G Copeland; Francine Morris; Jerry Jacob; Philip Yeagle; David S Williams; Monika Damek-Poprawa
Journal: Biochemistry Date: 2007-02-06 Impact factor: 3.162