[Evaluation exposition to polycyclic aromatic hydrocarbons of pregnant women who smoking tobacco].

The aim of the study was to evaluate the exposure of smoking pregnant women (total number 52) to polycyclic aromatic hydrocarbons (PAH) on the base of determination of 1-hydroxypyrene in urine. Standardised survey questionnaire and determination of cotinine in urine estimated the smoking habit. In the case of smoking women the mean concentration of cotinine was 362+/-320 ng/mg creatinine, passive smokers had cotinine concentration 32+/-6 ng/mg creatinine and non smokers below 5 ng/mg creatinine. In the urine of pregnant women, 1-hydroxypyrene a biomarker of PAH exposure was measured. The urine of smokers contained 0.17+/-0.18 micromol/mol creatinine, passive smokers 0.11+/-0.20 pmol/mol creatinine and nonsmokers 0.10+/-0.12 pmol/mol creatinine. The obtained results confirmed the higher risk of exposure to PAH in group of smoking pregnant women, however cigarette smoke are not only one source of these cancerogenic compounds.