AIM: To determine the effects of the calcineurin inhibitors, cyclosporine and tacrolimus, on hepatitis C virus (HCV) replication and activity of recurrent hepatitis C in patients post liver transplantation. METHODS: The data of a cohort of 107 patients who received liver transplantation for HCV-associated liver cirrhosis between 1999 and 2003 in our center were retrospectively analyzed. The level of serum HCV-RNA and the activity of recurrent hepatitis were compared between 47 patients who received either cyclosporine or tacrolimus as the primary immunosuppressive agent and an otherwise similar immunosuppressive regimen which did not lead to biliary complications within the first 12 mo after transplantation. RESULTS: HCV-RNA increased within 3 mo after transplantation but the differences between the cyclosporine group and the tacrolimus group were insignificant (P=0.49 at 12 mo). In addition, recurrent hepatitis as determined by serum transaminases and histological grading of portal inflammation and fibrosis showed no significant difference after 12 mo (P=0.34). CONCLUSION: Cyclosporine or tacrolimus as a primary immunosuppressive agent does not influence the induction or severity of recurrent hepatitis in HCV-infected patients after liver transplantation.
AIM: To determine the effects of the calcineurin inhibitors, cyclosporine and tacrolimus, on hepatitis C virus (HCV) replication and activity of recurrent hepatitis C in patients post liver transplantation. METHODS: The data of a cohort of 107 patients who received liver transplantation for HCV-associated liver cirrhosis between 1999 and 2003 in our center were retrospectively analyzed. The level of serum HCV-RNA and the activity of recurrent hepatitis were compared between 47 patients who received either cyclosporine or tacrolimus as the primary immunosuppressive agent and an otherwise similar immunosuppressive regimen which did not lead to biliary complications within the first 12 mo after transplantation. RESULTS:HCV-RNA increased within 3 mo after transplantation but the differences between the cyclosporine group and the tacrolimus group were insignificant (P=0.49 at 12 mo). In addition, recurrent hepatitis as determined by serum transaminases and histological grading of portal inflammation and fibrosis showed no significant difference after 12 mo (P=0.34). CONCLUSION:Cyclosporine or tacrolimus as a primary immunosuppressive agent does not influence the induction or severity of recurrent hepatitis in HCV-infectedpatients after liver transplantation.
Authors: M Prieto; M Berenguer; J M Rayón; J Córdoba; L Argüello; D Carrasco; A García-Herola; V Olaso; M De Juan; M Gobernado; J Mir; J Berenguer Journal: Hepatology Date: 1999-01 Impact factor: 17.425
Authors: K Ishak; A Baptista; L Bianchi; F Callea; J De Groote; F Gudat; H Denk; V Desmet; G Korb; R N MacSween Journal: J Hepatol Date: 1995-06 Impact factor: 25.083
Authors: Paul Martin; Ronald W Busuttil; Robert M Goldstein; Jeffrey S Crippin; Goran B Klintmalm; William E Fitzsimmons; Carol Uleman Journal: Liver Transpl Date: 2004-10 Impact factor: 5.799
Authors: Zhe Liu; John M Robida; Sreedhar Chinnaswamy; Guanghui Yi; Jason M Robotham; Heather B Nelson; Andre Irsigler; C Cheng Kao; Hengli Tang Journal: Hepatology Date: 2009-07 Impact factor: 17.425
Authors: Roberto J Firpi; Consuelo Soldevila-Pico; Giuseppe G Morelli; Roniel Cabrera; Cynthia Levy; Virginia C Clark; Amitabh Suman; Anthony Michaels; Chaoru Chen; David R Nelson Journal: Dig Dis Sci Date: 2010-01 Impact factor: 3.487