Literature DB >> 16520990

Comparative study of eight oxytocin antagonists by simulated annealing.

Balázs Jójárt1, Arpád Márki.   

Abstract

In this study, eight oxytocin (OT) antagonists were subjected to conformational analysis. By means of simulated annealing, 2,000 structures were generated to sample the conformational space. The preferred main-chain and side-chain dihedral angles, intramolecular H-bond interactions (types 1<--4 and 1<--3), and secondary-structure elements (beta-turns) were determined in the series of compounds. The influence of the modified amino acid on these structural elements was established; the values determined will be used as filtration criterion in preliminary research.

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Year:  2006        PMID： 16520990     DOI： 10.1007/s00894-006-0104-4

Source DB:  PubMed          Journal:  J Mol Model        ISSN： 0948-5023            Impact factor:   1.810


  8 in total

1.  Noncompetitive nature of oxytocin antagonists with general structure Mpa(1)Xxx(2)Sar(7)Arg(8).

Authors:  J Havass; K Bakos; A Márki; R Gáspár; L Gera; J M Stewart; F Fülöp; G K Tóth; I Zupkó; G Falkay
Journal:  Peptides       Date:  2002-08       Impact factor: 3.750

2.  Uterine contractility and oxytocin sensitivity in preterm, term, and postterm pregnancy.

Authors:  K Takahashi; F Diamond; J Bieniarz; H Yen; L Burd
Journal:  Am J Obstet Gynecol       Date:  1980-03-15       Impact factor: 8.661

3.  Synthetic antagonists of the myometrial response to vasopressin and oxytocin.

Authors:  P Melin; J Trojnar; B Johansson; H Vilhardt; M Akerlund
Journal:  J Endocrinol       Date:  1986-10       Impact factor: 4.286

4.  In vitro degradation of some arginine-vasopressin analogs by homogenates of rat kidney, liver and serum.

Authors:  Z Grzonka; F Kasprzykowski; L Lubkowska; K Darłak; T A Hahn; A F Spatola
Journal:  Pept Res       Date:  1991 Sep-Oct

5.  Synthesis and some pharmacological properties of [4-threonine,7-sarcosine]oxytocin, a peptide with high oxytocic potency, and of [4-threonine,7-N-methylalanine]oxytocin.

Authors:  Z Grzonka; B Lammek; D Gazis; I L Schwartz
Journal:  J Med Chem       Date:  1983-12       Impact factor: 7.446

6.  Treatment of preterm labor with the oxytocin antagonist atosiban.

Authors:  T M Goodwin; G Valenzuela; H Silver; R Hayashi; G W Creasy; R Lane
Journal:  Am J Perinatol       Date:  1996-04       Impact factor: 1.862

7.  Oxytocin receptors and human parturition: a dual role for oxytocin in the initiation of labor.

Authors:  A R Fuchs; F Fuchs; P Husslein; M S Soloff; M J Fernström
Journal:  Science       Date:  1982-03-12       Impact factor: 47.728

8.  Design of potent oxytocin antagonists featuring D-tryptophan at position 2.

Authors:  G Flouret; W Brieher; K Mahan; L Wilson
Journal:  J Med Chem       Date:  1991-02       Impact factor: 7.446
  8 in total
  1 in total

1.  Conformational determinants of phosphotyrosine peptides complexed with the Src SH2 domain.

Authors:  Joseph Nachman; Gerry Gish; Cristina Virag; Tony Pawson; Régis Pomès; Emil Pai
Journal:  PLoS One       Date:  2010-06-21       Impact factor: 3.240
  1 in total

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