Literature DB >> 1652015

Synthesis and biological activity of 2'-deoxy-4'-thio pyrimidine nucleosides.

J A Secrist1, K N Tiwari, J M Riordan, J A Montgomery.   

Abstract

2'-Deoxy-4'-thiocytidine (7 beta), 2'-deoxy-4'-thiouridine (9), and 4'-thiothymidine (10) have been synthesized and evaluated for cytotoxicity in vitro. All these compounds were cytotoxic to L1210, H-Ep-2, and CCRF-CEM cell lines. 4'-Thiothymidine was also active against herpes simplex 1 and human cytomegalovirus in cell culture.

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Year:  1991        PMID： 1652015     DOI： 10.1021/jm00112a007

Source DB:  PubMed          Journal:  J Med Chem        ISSN： 0022-2623            Impact factor:   7.446


  18 in total

1.  DNA containing 4'-thio-2'-deoxycytidine inhibits methylation by HhaI methyltransferase.

Authors:  S Kumar; J R Horton; G D Jones; R T Walker; R J Roberts; X Cheng
Journal:  Nucleic Acids Res       Date:  1997-07-15       Impact factor: 16.971

2.  KAY-2-41, a novel nucleoside analogue inhibitor of orthopoxviruses in vitro and in vivo.

Authors:  Sophie Duraffour; Robert Drillien; Kazuhiro Haraguchi; Jan Balzarini; Dimitri Topalis; Joost J van den Oord; Graciela Andrei; Robert Snoeck
Journal:  Antimicrob Agents Chemother       Date:  2013-10-14       Impact factor: 5.191

Review 3.  Cytomegalovirus antivirals and development of improved animal models.

Authors:  Alistair McGregor; K Yeon Choi
Journal:  Expert Opin Drug Metab Toxicol       Date:  2011-09-01       Impact factor: 4.481

4.  Novel DNA methyltransferase-1 (DNMT1) depleting anticancer nucleosides, 4'-thio-2'-deoxycytidine and 5-aza-4'-thio-2'-deoxycytidine.

Authors:  Jaideep V Thottassery; Vijaya Sambandam; Paula W Allan; Joseph A Maddry; Yulia Y Maxuitenko; Kamal Tiwari; Melinda Hollingshead; William B Parker
Journal:  Cancer Chemother Pharmacol       Date:  2014-06-08       Impact factor: 3.333

5.  Synthesis and properties of oligodeoxynucleotides containing the analogue 2'-deoxy-4'-thiothymidine.

Authors:  E L Hancox; B A Connolly; R T Walker
Journal:  Nucleic Acids Res       Date:  1993-07-25       Impact factor: 16.971

6.  HPLC method development, validation, and impurity characterization of a potent antitumor nucleoside, T-dCyd (NSC 764276).

Authors:  Mingtao Liu; Jennie Wang; Paul Liu
Journal:  J Pharm Biomed Anal       Date:  2016-09-09       Impact factor: 3.935

7.  4'-Thio-oligo-beta-D-ribonucleotides: synthesis of beta-4'-thio-oligouridylates, nuclease resistance, base pairing properties, and interaction with HIV-1 reverse transcriptase.

Authors:  L Bellon; J L Barascut; G Maury; G Divita; R Goody; J L Imbach
Journal:  Nucleic Acids Res       Date:  1993-04-11       Impact factor: 16.971

8.  Inhibition of herpesvirus replication by 5-substituted 4'-thiopyrimidine nucleosides.

Authors:  Mark N Prichard; Debra C Quenelle; Caroll B Hartline; Emma A Harden; Geraldine Jefferson; Samuel L Frederick; Shannon L Daily; Richard J Whitley; Kamal N Tiwari; Joseph A Maddry; John A Secrist; Earl R Kern
Journal:  Antimicrob Agents Chemother       Date:  2009-09-21       Impact factor: 5.191

9.  Investigation of some properties of oligodeoxynucleotides containing 4'-thio-2'-deoxynucleotides: duplex hybridization and nuclease sensitivity.

Authors:  G D Jones; E A Lesnik; S R Owens; L M Risen; R T Walker
Journal:  Nucleic Acids Res       Date:  1996-11-01       Impact factor: 16.971

10.  The crystal structure analysis of d(CGCGAASSCGCG)2, a synthetic DNA dodecamer duplex containing four 4'-thio-2'-deoxythymidine nucleotides.

Authors:  T J Boggon; E L Hancox; K E McAuley-Hecht; B A Connolly; W N Hunter; T Brown; R T Walker; G A Leonard
Journal:  Nucleic Acids Res       Date:  1996-03-01       Impact factor: 16.971
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