| Literature DB >> 16519749 |
Heikki T Huhtinen1, Juha O Grönroos, Juha M Grönroos, Jaakko Uksila, Michael H Gelb, Timo J Nevalainen, V Jukka O Laine.
Abstract
Group IIA phospholipase A2 (PLA2-IIA) is an enzyme which has important roles in inflammation and infection. Recently, a novel human secretory PLA2 called group XIIA PLA2 (PLA2-XIIA) has been identified. Both PLA2-IIA and PLA2-XIIA are bactericidal against Gram-positive bacteria like many other secretory PLA2s. However, PLA2-XIIA is the only known PLA2 displaying significant bactericidal activity against the Gram-negative bacterium Escherichia coli. We examined the antibacterial properties of recombinant human PLA2-IIA and PLA2-XIIA against Helicobacter pylori, a Gram-negative bacterium, in vitro. PLA2-IIA was not bactericidal against H. pylori, whereas PLA2-XIIA effectively killed H. pylori at a concentration of 50 microg/ml but was not bactericidal at concentrations of 0.5 microg/ml and 5 microg/ml.Entities:
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Year: 2006 PMID： 16519749 DOI： 10.1111/j.1600-0463.2006.apm_330.x
Source DB: PubMed Journal: APMIS ISSN： 0903-4641 Impact factor: 3.205