| Literature DB >> 16518413 |
Abstract
Tumor microenvironment is essential for tumor cell proliferation, angiogenesis, invasion and metastasis through its provision of survival signals, secretion of growth and pro-angiogenic factors, and direct adhesion molecule interactions. This review examines its importance in the induction of an angiogenic response in multiple myeloma (MM). The encouraging results of preclinical and clinical trials in which MM has been treated by targeting the tumor microenvironment are also discussed.Entities:
Mesh:
Year: 2006 PMID: 16518413 DOI: 10.1038/sj.onc.1209456
Source DB: PubMed Journal: Oncogene ISSN: 0950-9232 Impact factor: 9.867